Effects of oxcarbazepine on monoamines content in hippocampus and head and body shakes and sleep patterns in kainic acid-treated rats

被引：3

作者：

Alfaro-Rodriguez, Alfonso ^{[1
]}

Gonzalez-Pina, Rigoberto ^{[2
]}

Bueno-Nava, Antonio ^{[1
,3
]}

Arch-Tirado, Emilio ^{[4
]}

Avila-Luna, Alberto ^{[1
]}

Uribe-Escamilla, Rebeca ^{[1
]}

Vargas-Sanchez, Javier ^{[1
]}

机构：

[1] SSA, Inst Nacl Rehabil, Dept Neurofisiol, Lab Neuroquim, Mexico City 14389, DF, Mexico

[2] SSA, Inst Nacl Rehabil, Dept Neurofisiol, Lab Neuroplasticidad, Mexico City 14389, DF, Mexico

[3] SSA, Inst Nacl Rehabil, Dept Neurofisiol, Lab Cromatograf & Microdialisis, Mexico City 14389, DF, Mexico

[4] SSA, Inst Nacl Rehabil, Dept Neurofisiol, Lab Bioacust, Mexico City 14389, DF, Mexico

来源：

METABOLIC BRAIN DISEASE | 2011年 / 26卷 / 03期

关键词：

Oxcarbazepine; Monoamine neurotransmitters; Kainic acid; Head and body shakes; Seizure; Sleep patterns; INDUCED STATUS EPILEPTICUS; TEMPORAL-LOBE EPILEPSY; IN-VITRO; PHARMACODYNAMIC MARKERS; ANTICONVULSANT ACTION; ANTIEPILEPTIC DRUGS; RECEPTOR ACTIVATION; 5-HT1A RECEPTORS; SEROTONIN; DOPAMINE;

D O I：

10.1007/s11011-011-9254-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this work was to analyze the effect of oxcarbazepine (OXC) on sleep patterns, "head and body shakes" and monoamine neurotransmitters level in a model of kainic-induced seizures. Adult Wistar rats were administered kainic acid (KA), OXC or OXC + KA. A polysomnographic study showed that KA induced animals to stay awake for the whole initial 10 h. OXC administration 30 min prior to KA diminished the effect of KA on the sleep parameters. As a measure of the effects of the drug treatments on behavior, head and body shakes were visually recorded for 4 h after administration of KA, OXC + KA or saline. The presence of OXC diminished the shakes frequency. 4 h after drug application, the hippocampus was dissected out, and the content of monoamines was analyzed. The presence of OXC still more increased serotonin, 5-hidroxyindole acetic acid, dopamine, and homovanilic acid, induced by KA.

引用

页码：213 / 220

页数：8

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