Disseminated histoplasmosis in an immunocompetent patient with COVID-19 pneumonia

被引:11
|
作者
Del Nogal, Genesis Perez [1 ]
Mata, Andres [2 ]
Ernest, Prince [1 ]
Salinas, Ivania [1 ]
机构
[1] TTUHSC SOM Permian Basin, Internal Med, Odessa, TX 79763 USA
[2] Univ Carabobo, Sch Med, Valencia, Carabobo, Venezuela
关键词
COVID-19; infectious diseases; pneumonia (infectious disease); adult intensive care; TB and other respiratory infections;
D O I
10.1136/bcr-2021-247617
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Disseminated histoplasmosis is usually associated with immunosuppressive conditions like AIDS. People with respiratory distress syndrome secondary to SARS-CoV-2 pneumonia are vulnerable to bacterial infections. Additionally, coinfection with fungal pathogens should be considered as a differential diagnosis even in immunocompetent patients who remain on mechanical ventilation secondary to COVID-19. The case presents a 61-year-old immunocompetent man, admitted to the medical ward due to COVID-19 pneumonia. Despite appropriate therapy, the patient required transfer to the intensive care unit for invasive mechanical ventilation. He remained critically ill with worsening respiratory failure. Two weeks later, coinfection by disseminated histoplasmosis was detected. After immediate treatment with amphotericin B and itraconazole, the patient tolerated weaning from mechanical ventilation until extubation. Awareness of this possible fungal coinfection in immunocompetent patients is essential to reduce delays in diagnosis and treatment, and prevent severe illness and death.
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页数:4
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