High expression of ZNF93 promotes proliferation and migration of ovarian cancer cells and relates to poor prognosis

被引：0
作者：
Cui, Xiao-Xiao [1 ,2 ]
Zhou, Chen [3 ]
Lu, Huan [2 ]
Han, Yan-Li [1 ]
Wang, Feng-Mian [2 ]
Fan, Wei-Rong [2 ]
Ren, Yuan [1 ,2 ]
Zhang, Rong [1 ,2 ]
机构：
[1] Anhui Univ Sci & Technol, Huainan, Peoples R China
[2] Hlth Sci Affiliated Sixth Peoples Hosp, Dept Obstet & Gynecol, South Campus, Shanghai, Peoples R China
[3] Changzhou 2 Peoples Hosp, Dept Gynecol, Changzhou, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2020年 / 13卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Ovarian cancer; transcription factor ZNF93; small interfering siRNA; cell proliferation; cell migration; STATISTICS; APOPTOSIS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ovarian cancer (OC) is most common type of gynecologic cancer and is frequently lethal. It is important to determine the pathologic mechanisms underlying OC. ZNF93 is a member of the zinc finger protein family. Abnormal expression of ZNF93 has been observed in various tumor cells. However, its clinical significance and biologic function in ovarian cancer remain unclear. In the present study, we established that ZNF93 expression was highly up-regulated in OC samples and was closely correlated with clinical stage, indicating poor prognosis. We then established that ZNF93 promoted OC cell proliferation and migration. The results of our study may provide insight into the use of ZNF93 as a marker of clinical outcome and as a potential therapeutic target in OC.
引用
收藏
页码：944 / 953
页数：10
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