Mitochondrial Dysfunction in Neural Injury

被引：85
作者：
Zhao, Xiu-Yun [1 ,2 ,3 ,4 ]
Lu, Mei-Hong [1 ,2 ,3 ,4 ]
Yuan, De-Juan [1 ,2 ,5 ]
Xu, De-En [6 ]
Yao, Pei-Pei [1 ,2 ,3 ,4 ]
Ji, Wen-Li [1 ,2 ,3 ,4 ]
Chen, Hong [1 ,2 ,3 ,4 ]
Liu, Wen-Long [1 ,2 ,3 ,4 ]
Yan, Chen-Xiao [1 ,2 ,3 ,4 ]
Xia, Yi-Yuan [1 ,2 ,3 ,4 ]
Li, Shao [5 ]
Tao, Jin [1 ,2 ,7 ,8 ]
Ma, Quan-Hong [1 ,2 ]
机构：
[1] Soochow Univ, Inst Neurosci, Suzhou, Peoples R China
[2] Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou, Peoples R China
[3] Soochow Univ, Affiliated Hosp 2, Dept Neurol, Suzhou, Peoples R China
[4] Soochow Univ, Affiliated Hosp 2, Suzhou Clin Res Ctr Neurol Dis, Suzhou, Peoples R China
[5] Dalian Med Univ, Liaoning Prov Key Lab Cerebral Dis, Dept Physiol, Dalian, Peoples R China
[6] Wuxi 2 Peoples Hosp, Wuxi, Peoples R China
[7] Soochow Univ, Dept Physiol & Neurobiol, Coll Med, Suzhou, Peoples R China
[8] Soochow Univ, Ctr Ion Channelopathy, Coll Med, Suzhou, Peoples R China
来源：
FRONTIERS IN NEUROSCIENCE | 2019年 / 13卷
基金：
中国国家自然科学基金;
关键词：
mitochondrial dysfunction; neural injury; mitochondria; neurodegeneration; neurological disorders; AMYLOID PRECURSOR PROTEIN; PERMEABILITY TRANSITION PORE; ACUTE ISCHEMIC-STROKE; TARGETED ANTIOXIDANT MITOQ; OXYGEN-FREE RADICALS; ALPHA-SYNUCLEIN; NITRIC-OXIDE; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE;
D O I：
10.3389/fnins.2019.00030
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Mitochondria are the double membrane organelles providing most of the energy for cells. In addition, mitochondria also play essential roles in various cellular biological processes such as calcium signaling, apoptosis, ROS generation, cell growth, and cell cycle. Mitochondrial dysfunction is observed in various neurological disorders which harbor acute and chronic neural injury such as neurodegenerative diseases and ischemia, hypoxia-induced brain injury. In this review, we describe how mitochondrial dysfunction contributes to the pathogenesis of neurological disorders which manifest chronic or acute neural injury.
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页数：14
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