Synthesis and Biological Activity of Two Kinds of Nitrogen Mustard Derivatives

被引：0
作者：
Xu, Fenghua [1 ,2 ]
Gan, Ying [2 ]
Zhang, Yahong [2 ]
Luo, Wen [2 ]
Ma, Hongxia [2 ]
Wang, Chaojie [2 ]
Zhao, Jin [1 ,2 ]
机构：
[1] Henan Univ, Coll Chem & Chem Engn, Kaifeng 475004, Peoples R China
[2] Henan Univ, Key Lab Nat Med & Immunoengn Henan Prov, Kaifeng 475004, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 31卷 / 07期
关键词：
nitrogen mustard derivative; synthesis; biological activity; ANTITUMOR; RECEPTOR; DNA;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Three aniline nitrogen mustard and six naphthalimide-nitrogen mustard derivatives were designed and synthesized. The structures of the synthesized compounds were confirmed by H-1 NMR, C-13 NMR, ESI-MS techniques and elemental analysis. The prelimilary antitumor activity was evaluated on HL-60, K562 and SMMC-7721 cell lines by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. The results demonstrated that target compounds exhibited antitumor activity for HL-60 and the activity of compound 5 was superior to commercial drug melphalan. Besides, the activity of compound 5a against SMMC-7721 cells is more selectivity than that of QSG-7701 cell lines.
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收藏
页码：1122 / 1126
页数：5
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