Synthesis and Biological Activity of Two Kinds of Nitrogen Mustard Derivatives

被引:0
作者
Xu, Fenghua [1 ,2 ]
Gan, Ying [2 ]
Zhang, Yahong [2 ]
Luo, Wen [2 ]
Ma, Hongxia [2 ]
Wang, Chaojie [2 ]
Zhao, Jin [1 ,2 ]
机构
[1] Henan Univ, Coll Chem & Chem Engn, Kaifeng 475004, Peoples R China
[2] Henan Univ, Key Lab Nat Med & Immunoengn Henan Prov, Kaifeng 475004, Peoples R China
关键词
nitrogen mustard derivative; synthesis; biological activity; ANTITUMOR; RECEPTOR; DNA;
D O I
暂无
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Three aniline nitrogen mustard and six naphthalimide-nitrogen mustard derivatives were designed and synthesized. The structures of the synthesized compounds were confirmed by H-1 NMR, C-13 NMR, ESI-MS techniques and elemental analysis. The prelimilary antitumor activity was evaluated on HL-60, K562 and SMMC-7721 cell lines by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. The results demonstrated that target compounds exhibited antitumor activity for HL-60 and the activity of compound 5 was superior to commercial drug melphalan. Besides, the activity of compound 5a against SMMC-7721 cells is more selectivity than that of QSG-7701 cell lines.
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页码:1122 / 1126
页数:5
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