Synthesis and in vitro study of novel 7-O-acyl derivatives of Oroxylin A as antibacterial agents

被引：41
作者：
Babu, KS
Babu, TH
Srinivas, PV
Sastry, BS
Kishore, KH
Murty, USN
Rao, JM [1 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem 1, Hyderabad 500007, Andhra Pradesh, India
[2] Indian Inst Chem Technol, Div Biol, Hyderabad 500007, Andhra Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 17期
关键词：
Oroxylin A; acylation; antibacterial activity; Oroxylum indicum;
D O I：
10.1016/j.bcml.2005.05.045
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of Oroxylin A derivatives, prepared by alkylation and condensation, were fully characterized by spectroscopic methods. All the derivatives were screened for antibacterial activity against a panel of susceptible and resistant Gram-positive and Gram-negative organisms. It was observed that acylation of 7-OH group in Oroxylin A significantly enhanced the activity as compared to their parent compound (Oroxylin A). (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码：3953 / 3956
页数：4
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