Protein-DNA Recognition Triggered by a DNA Conformational Switch

被引：41

作者：

Bouvier, Benjamin ^{[1
]}

Zakrzewska, Krystyna ^{[1
]}

Lavery, Richard ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, UMR 5086, IBCP, F-69367 Lyon, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 29期

关键词：

conformational transitions; DNA; molecular dynamics; protein-DNA recognition; proteins; FACILITATED TARGET LOCATION; BINDING-SITE; SRY; DIFFUSION;

D O I：

10.1002/anie.201101417

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Making the switch: The analysis of molecular dynamics simulations of the SRY-protein-DNA complex shows that, when the SRY protein approaches the correct DNA target sequence, it triggers a DNA conformational switch and allows the passage from a nonspecifically bound to a specifically bound state (see picture; dAXC=distance between DNA and SRY protein). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6516 / 6518

页数：3

共 18 条

[1] Diffusion constant of a nonspecifically bound protein undergoing curvilinear motion along DNA [J].

Bagchi, Biman ;

Blainey, Paul C. ;

Xie, X. Sunney .

JOURNAL OF PHYSICAL CHEMISTRY B, 2008, 112 (19) :6282-6284

[2] Nonspecifically bound proteins spin while diffusing along DNA [J].

Blainey, Paul C. ;

Luo, Guobin ;

Kou, S. C. ;

Mangel, Walter F. ;

Verdine, Gregory L. ;

Bagchi, Biman ;

Xie, X. Sunney .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (12) :1224-U34

[3] Sliding and jumping of single EcoRV restriction enzymes on non-cognate DNA [J].

Bonnet, Isabelle ;

Biebricher, Andreas ;

Porte, Pierre-Louis ;

Loverdo, Claude ;

Benichou, Olivier ;

Voituriez, Raphael ;

Escude, Christophe ;

Wende, Wolfgang ;

Pingoud, Alfred ;

Desbiolles, Pierre .

NUCLEIC ACIDS RESEARCH, 2008, 36 (12) :4118-4127

[4] A Free Energy Pathway for the Interaction of the SRY Protein with Its Binding Site on DNA from Atomistic Simulations [J].

Bouvier, Benjamin ;

Lavery, Richard .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (29) :9864-+

[5] Nonspecific DNA-Protein Interaction: Why Proteins Can Diffuse along DNA [J].

Dahirel, Vincent ;

Paillusson, Fabien ;

Jardat, Marie ;

Barbi, Maria ;

Victor, Jean-Marc .

PHYSICAL REVIEW LETTERS, 2009, 102 (22)

[6] Protein-DNA recognition: Breaking the combinatorial barrier [J].

Deremble, Cyril ;

Lavery, Richard ;

Zakrzewska, Krystyna .

COMPUTER PHYSICS COMMUNICATIONS, 2008, 179 (1-3) :112-119

[7] Protein Sliding along DNA: Dynamics and Structural Characterization [J].

Givaty, Ohad ;

Levy, Yaakov .

JOURNAL OF MOLECULAR BIOLOGY, 2009, 385 (04) :1087-1097

[8] Visualizing one-dimensional diffusion of proteins along DNA [J].

Gorman, Jason ;

Greene, Eric C. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (08) :768-774

[9] DEFINITION OF A CONSENSUS DNA-BINDING SITE FOR SRY [J].

HARLEY, VR ;

LOVELLBADGE, R ;

GOODFELLOW, PN .

NUCLEIC ACIDS RESEARCH, 1994, 22 (08) :1500-1501

[10] DNA-BINDING ACTIVITY OF RECOMBINANT SRY FROM NORMAL MALES AND XY FEMALES [J].

HARLEY, VR ;

JACKSON, DI ;

HEXTALL, PJ ;

HAWKINS, JR ;

BERKOVITZ, GD ;

SOCKANATHAN, S ;

LOVELLBADGE, R ;

GOODFELLOW, PN .

SCIENCE, 1992, 255 (5043) :453-456

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