Gender-specificities in Alzheimer's disease and mild cognitive impairment

被引：63

作者：

Beinhoff, U. ^{[1
]}

Tumani, H. ^{[2
]}

Brettschneider, J. ^{[2
]}

Bittner, D. ^{[2
]}

Riepe, M. W. ^{[1
]}

机构：

[1] Charite Med Univ, Mental Hlth & Old Age Psychiat, Dept Psychiat, D-14050 Berlin, Germany

[2] Univ Ulm, Dept Neurol, D-7900 Ulm, Germany

来源：

JOURNAL OF NEUROLOGY | 2008年 / 255卷 / 01期

关键词：

Alzheimer's disease; mild cognitive impairment; episodic memory; neuropsychology; domain specificity; cerebrospinal fluid; tau protein;

D O I：

10.1007/s00415-008-0726-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Amnestic Mild Cognitive Impairment (MCI) is a condition with an increased risk for developing Alzheimer's disease (AD). Presently, gender differences are neglected in the assessment of MCI and AD. Methods We examined verbal and visuospatial episodic memory in 143 subjects diagnosed as healthy controls (HC; N = 48, Mini-Mental State Examination (MMSE) 29.2 +/- 1.0 (mean +/- standard deviation)), MCI (N = 43,MMSE 28.5 +/- 1.4), and AD (N = 49, MMSE 25.1 +/- 2.2). Results Female HC and MCI subjects performed better on verbal episodic memory tasks than males. In contrast, visuospatial episodic memory was better in male than female AD patients. Conclusions We interpret the results in light of a genderspecific cognitive reserve and conclude that the gender-specificity of neuropsychological performance needs to be accounted for in clinical diagnosis of Alzheimer's disease.

引用

页码：117 / 122

页数：6