The therapeutic potential of BRD4 in cardiovascular disease

被引：28

作者：

Lin, Shigang ^{[1
]}

Du, Lizhong ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Dept Neonatol, Childrens Hosp, Hangzhou, Peoples R China

来源：

HYPERTENSION RESEARCH | 2020年 / 43卷 / 10期

基金：

中国国家自然科学基金;

关键词：

BRD4; Cardiovascular disease; Atherosclerosis; Pulmonary arterial hypertension; Heart failure; PULMONARY ARTERIAL-HYPERTENSION; NF-KAPPA-B; ENDOTHELIAL DYSFUNCTION; INFLAMMATION; BROMODOMAIN; ATHEROSCLEROSIS; INHIBITION; PROLIFERATION; MECHANISMS; BINDING;

D O I：

10.1038/s41440-020-0459-4

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Bromodomain-containing protein 4 (BRD4) is a member of the bromodomain and extra terminal (BET) protein family that has gained wide attention in the field of cancer due to its role in the formation of super enhancers (SEs) and the regulation of oncogene expression. However, there is increasing evidence that BRD4 also plays a pivotal role in a variety of cardiovascular diseases, suggesting that understanding the mechanisms of BRD4 in these diseases is important to advance studies and clinical treatment. In this article, we summarize the mechanisms of BRD4 in cardiovascular diseases, including pulmonary arterial hypertension, heart failure, atherosclerosis, and hypertension. In addition, we discuss small molecule inhibitors of BRD4 as novel therapeutic strategies for cardiovascular diseases.

引用

页码：1006 / 1014

页数：9

共 77 条

[1] BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure [J].

Anand, Priti ;

Brown, Jonathan D. ;

Lin, Charles Y. ;

Qi, Jun ;

Zhang, Rongli ;

Artero, Pedro Calderon ;

Alaiti, M. Amer ;

Bullard, Jace ;

Alazem, Kareem ;

Margulies, Kenneth B. ;

Cappola, Thomas P. ;

Lemieux, Madeleine ;

Plutzky, Jorge ;

Bradner, James E. ;

Haldar, Saptarsi M. .

CELL, 2013, 154 (03) :569-582

[2] Trends and Outcomes of Pulmonary Arterial Hypertension-Related Hospitalizations in the United States Analysis of the Nationwide Inpatient Sample Database From 2001 Through 2012 [J].

Anand, Vidhu ;

Roy, Samit S. ;

Archer, Stephen L. ;

Weir, E. Kenneth ;

Garg, Sushil Kumar ;

Duval, Sue ;

Thenappan, Thenappan .

JAMA CARDIOLOGY, 2016, 1 (09) :1021-1029

[3] Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities [J].

Back, Magnus ;

Yurdagul, Arif, Jr. ;

Tabas, Ira ;

Oorni, Katariina ;

Kovanen, Petri T. .

NATURE REVIEWS CARDIOLOGY, 2019, 16 (07) :389-406

[4] Inhibition of BET proteins and epigenetic signaling as a potential treatment for osteoporosis [J].

Baud'huin, Marc ;

Lamoureux, Francois ;

Jacques, Camille ;

Calleja, Lidia Rodriguez ;

Quillard, Thibaut ;

Charrier, Celine ;

Amiaud, Jerome ;

Berreur, Martine ;

Brounais-LeRoyer, Benedicte ;

Owen, Robert ;

Reilly, Gwendolen C. ;

Bradner, James E. ;

Heymann, Dominique ;

Ory, Benjamin .

BONE, 2017, 94 :10-21

[5] The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology [J].

Bedard, Karen ;

Krause, Karl-Heinz .

PHYSIOLOGICAL REVIEWS, 2007, 87 (01) :245-313

[6] BET domain co-regulators in obesity, inflammation and cancer [J].

Belkina, Anna C. ;

Denis, Gerald V. .

NATURE REVIEWS CANCER, 2012, 12 (07) :465-477

[7] The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted [J].

Bonnet, Sebastien ;

Rochefort, Gael ;

Sutendra, Gopinath ;

Archer, Stephen L. ;

Haromy, Alois ;

Webster, Linda ;

Hashimoto, Kyoko ;

Bonnet, Sandra N. ;

Michelakis, Evangelos D. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (27) :11418-11423

[8] FOXM1 promotes pulmonary artery smooth muscle cell expansion in pulmonary arterial hypertension [J].

Bourgeois, Alice ;

Lambert, Caroline ;

Habbout, Karima ;

Ranchoux, Benoit ;

Paquet-Marceau, Stephanie ;

Trinh, Isabelle ;

Breuils-Bonnet, Sandra ;

Paradis, Renee ;

Nadeau, Valerie ;

Paulin, Roxane ;

Provencher, Steeve ;

Bonnet, Sebastien ;

Boucherat, Olivier .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2018, 96 (02) :223-235

[9] Oxidative stress in severe pulmonary hypertension [J].

Bowers, R ;

Cool, C ;

Murphy, RC ;

Tuder, RM ;

Hopken, MW ;

Flores, SC ;

Voelkel, NF .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 169 (06) :764-769

[10] NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis [J].

Brown, Jonathan D. ;

Lin, Charles Y. ;

Duan, Qiong ;

Griffin, Gabriel ;

Federation, Alexander J. ;

Paranal, Ronald M. ;

Bair, Steven ;

Newton, Gail ;

Lichtman, Andrew H. ;

Kung, Andrew L. ;

Yang, Tianlun ;

Wang, Hong ;

Luscinskas, Francis W. ;

Croce, Kevin J. ;

Bradner, James E. ;

Plutzky, Jorge .

MOLECULAR CELL, 2014, 56 (02) :219-231

← 1 2 3 4 5 6 7 8 →