Ruthenium-catalyzed oxidative coupling of 2-aryl-4-quinazolinones with olefins: synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one motifs

被引：26

作者：

Zheng, Yong ^{[1
]}

Song, Wei-Bin ^{[1
]}

Zhang, Shu-Wei ^{[1
]}

Xuan, Li-Jiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 23期

关键词：

C-H OLEFINATION; ONE-POT SYNTHESIS; LUOTONIN-A; ORTHO-ALKENYLATION; BOND ACTIVATION; QUINAZOLINONES; ALKENES; FUNCTIONALIZATION; ALKALOIDS; ARYLATION;

D O I：

10.1039/c5ob00601e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A ruthenium-catalyzed oxidative coupling of 2-aryl-quinazolinones with olefins via C-H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construction of pyrrolo[2,1-b]quinazolin-9(1H)-one scaffolds.

引用

收藏

页码：6474 / 6478

页数：5

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