Ruthenium-catalyzed oxidative coupling of 2-aryl-4-quinazolinones with olefins: synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one motifs

被引：26
作者：
Zheng, Yong [1 ]
Song, Wei-Bin [1 ]
Zhang, Shu-Wei [1 ]
Xuan, Li-Jiang [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 23期
关键词：
C-H OLEFINATION; ONE-POT SYNTHESIS; LUOTONIN-A; ORTHO-ALKENYLATION; BOND ACTIVATION; QUINAZOLINONES; ALKENES; FUNCTIONALIZATION; ALKALOIDS; ARYLATION;
D O I：
10.1039/c5ob00601e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A ruthenium-catalyzed oxidative coupling of 2-aryl-quinazolinones with olefins via C-H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construction of pyrrolo[2,1-b]quinazolin-9(1H)-one scaffolds.
引用
收藏
页码：6474 / 6478
页数：5
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