The chemical constituents from Urtica fissa leaves

被引：19

作者：

Wang, Meng-Yue ^{[1
]}

Yang, Yan ^{[1
]}

Zhou, Xi-Yan ^{[1
]}

Wang, Shang-Shang ^{[1
]}

Duan, Shi-Xin ^{[1
]}

Li, Xiao-Bo ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2018年 / 20卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Urticaceae; Urtica fissa; secolignan; ceramide; anti-inflammation; ROOTS; CERAMIDE;

D O I：

10.1080/10286020.2017.1383397

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new ceramide urticamide (1), two new secolignans urticalactones I (2) and ? (3), and a new flavonoid glycoside urticaside (4), together with 15 known compounds (4-19), were isolated from the leaves of Urtica fissa, a folk medicine for rheumatism arthritis in China. The active evaluation results showed that 1, 2, 3, 8, and 13 possessed the potent anti-inflammatory. They could inhibit the release of NO and TNF- in lipopolysaccharide(LPS) stimulated RAW 264.7 cells, with IC50 values less than 4.0M. [GRAPHICS] .

引用

页码：709 / 718

页数：10

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