Serotonin/5-hydroxytryptamine (5-HT) physiology

被引：4
作者：
Redelinghuys, C. [1 ]
机构：
[1] Univ Witwatersrand, Dept Anaesthesia, Johannesburg, South Africa
来源：
SOUTHERN AFRICAN JOURNAL OF ANAESTHESIA AND ANALGESIA | 2020年 / 26卷 / 06期
关键词：
serotonin; 5-hydroxytryptamine; physiology; SEROTONIN; PHARMACOLOGY; BIOLOGY;
D O I：
10.36303/SAJAA.2020.26.6.S3.2561
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Serotonin has a pervasive presence within both the central and peripheral nervous systems. Peripherally, serotonin stimulates various functions such as vasoconstriction, uterine contraction, bronchoconstriction, and platelet aggregation. Centrally acting serotonin inhibits excitatory neurotransmission and modulates alertness, concentration, emotions and mood, sexual behaviour, appetite, nociception and aggression. In addition to its extensive physiological role in the body, it is also the cause of certain diseases and the target of several pharmacological therapies. This review summarises the physiology of serotonin in humans and the clinical applications that are of relevance within anaesthesia.
引用
收藏
页码：S149 / S152
页数：4
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