PAIN MECHANISMS IN OSTEOARTHRITIS AND CURRENT THERAPEUTIC APPROACHES

被引:0
作者
Ergin, Sureyya [1 ]
机构
[1] Ankara Univ, Tip Fak, FTR Anabilim Dali, TR-06100 Ankara, Turkey
来源
TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI | 2011年 / 14卷
关键词
Osteoarthritis; Pain; Therapeutic; INTERLEUKIN-1 RECEPTOR ANTAGONIST; INTRAARTICULAR INJECTION; KNEE; ASSOCIATION; NEURONS; LEPTIN;
D O I
暂无
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Osteoarthritic pain is the most common and important symptom in osteoarthritis.Osteoarthritic pain has complicated and complex properties. Articular tissues,except articular cartilage, have rich nosiseptive network. With the stimulation of nociceptive system pain begins.Tissue destruction, inflammation,mechanical stres can cause harmful stimuli. Harmful stimuli have thermal, chemical and mechanical features. Pharmacological and non-pharmacological methods should be carried out for the treatment of OA.The drugs used in medical treatment of OA are symptom and disease modifying osteoarthritic drugs.
引用
收藏
页码:63 / 67
页数:5
相关论文
共 27 条
[11]   Increased movement pain in osteoarthritis of the hands is associated with Aβ-mediated cutaneous mechanical sensitivity [J].
Farrell, MJ ;
Gibson, SJ ;
McMeeken, JM ;
Helme, RD .
JOURNAL OF PAIN, 2000, 1 (03) :229-242
[12]   The association of bone marrow lesions with pain in knee osteoarthritis [J].
Felson, DT ;
Chaisson, CE ;
Hill, CL ;
Totterman, SMS ;
Gale, ME ;
Skinner, KM ;
Kazis, L ;
Gale, DR .
ANNALS OF INTERNAL MEDICINE, 2001, 134 (07) :541-549
[13]   The sources of pain in knee osteoarthritis [J].
Felson, DT .
CURRENT OPINION IN RHEUMATOLOGY, 2005, 17 (05) :624-628
[14]   INTRA-ARTICULAR FLUID PRESSURE AND PAIN IN OSTEO-ARTHRITIS OF THE HIP [J].
GODDARD, NJ ;
GOSLING, PT .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 1988, 70 (01) :52-55
[15]   Relative impact of radiographic osteoarthritis and pain on quadriceps strength, proprioception, static postural sway and lower limb function [J].
Hall, MC ;
Mockett, SP ;
Doherty, M .
ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (07) :865-870
[16]  
Hill CL, 2001, J RHEUMATOL, V28, P1330
[17]   Subchondral cysts create increased intra-osseous stress in early knee OA: A finite element analysis using simulated lesions [J].
McErlain, David D. ;
Milner, Jaques S. ;
Ivanov, Todor G. ;
Jencikova-Celerin, Lubica ;
Pollmann, Steven I. ;
Holdsworth, David W. .
BONE, 2011, 48 (03) :639-646
[18]   Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression [J].
Mutabaruka, Marie-Solange ;
Aissa, Mohamed Aoulad ;
Delalandre, Aline ;
Lavigne, Martin ;
Lajeunesse, Daniel .
ARTHRITIS RESEARCH & THERAPY, 2010, 12 (01)
[19]  
Pelletier JP, 2001, J RHEUMATOL, V28, P814
[20]   Mechanisms of joint destruction, pain and disability in osteoarthritis [J].
Pinals, RS .
DRUGS, 1996, 52 :14-20