Mean corpuscular hemoglobin concentration correlates with prognosis of resected hepatocellular carcinoma

被引：8
|
作者：
Kong, Weihao [1 ,2 ,3 ,4 ]
Zheng, Jun [2 ,3 ,4 ]
Chen, Liang [2 ,3 ,4 ]
Zuo, Xiaomin [5 ]
Wang, Hengyi [1 ]
Wang, Xingyu [1 ]
Yao, Jia [2 ,3 ,4 ]
Chen, Wei [5 ]
机构：
[1] Anhui Med Univ, Affiliated Hosp 1, Dept Emergency Med, Hefei 230022, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Hepat Surg, Guangzhou 510630, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 3, Liver Transplantat Ctr, Guangzhou 510630, Peoples R China
[4] Sun Yat Sen Univ, Key Lab Liver Dis Biotherapy & Translat Med, Guangdong Higher Educ Inst, Guangdong Key Lab Liver Dis Res,Affiliated Hosp, Guangzhou 510630, Peoples R China
[5] Anhui Med Univ, Affiliated Hosp 1, Dept Gen Surg, Hefei 230022, Peoples R China
来源：
BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 04期
基金：
安徽省自然科学基金;
关键词：
hepatectomy; hepatocellular carcinoma; mean corpuscular hemoglobin concentration; overall survival; recurrence-free survival; TO-LYMPHOCYTE RATIO; LIVER RESECTION; ANEMIA; PLATELET; HYPOXIA; CANCER; CHEMOTHERAPY; NEUTROPHIL; SURVIVAL; IMPACT;
D O I：
10.2217/bmm-2019-0224
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: To evaluate the prognostic role of mean corpuscular hemoglobin concentration (MCHC) in hepatocellular carcinoma (HCC) after hepatectomy. Patients & methods: A total of 289 HCC patients were classified into two groups based on the cut-off value of MCHC. Significant prognostic factors were screened by univariate and multivariate analysis. Results: Low MCHC value was significantly associated with tumor diameter (p = 0.004) and vascular invasion (p = 0.038). Besides, Cox regression analysis showed that low MCHC was significantly associated with poor prognostic outcomes with HCC after hepatectomy (overall survival: hazard ratio: 0.372; 95% CI: 0.206-0.672; p = 0.001; recurrence-free survival: hazard ratio: 0.450; 95% confidence interval: 0.317-0.638; p < 0.001). Conclusion: Preoperative MCHC can predict prognosis for patients with HCC, and the lower MCHC value was associated with poor prognosis after hepatectomy.
引用
收藏
页码：257 / 269
页数：13
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