Palladium-Catalyzed Heck-Type Coupling via C-N Cleavage

被引：3
|
作者：
Fan, Weizheng [1 ]
Liu, Faming [1 ]
Feng, Bainian [1 ]
机构：
[1] Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Peoples R China
来源：
SYNLETT | 2015年 / 26卷 / 09期
基金：
中国国家自然科学基金;
关键词：
palladium-catalyzed; Heck-type coupling; C-N cleavage; control experiment; mechanism; CARBONYL-COMPOUNDS; DIRECT ARYLATION; MANNICH-BASES; BOND; CHALCONES; FUNCTIONALIZATION; (HETERO)ARENES; OLEFINATION; SEQUENCE; KETONES;
D O I：
10.1055/s-0034-1379911
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed Heck-type coupling method between arenes and ketone Mannich bases via C-N cleavage to synthesize chalcones is reported. This protocol offers good yields and tolerates a broad range of functional groups. Based on the extensive experimental data, we propose a plausible coulping mechanism.
引用
收藏
页码：1253 / 1257
页数：5
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