Palladium-Catalyzed Heck-Type Coupling via C-N Cleavage

被引：4

作者：

Fan, Weizheng ^{[1
]}

Liu, Faming ^{[1
]}

Feng, Bainian ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Peoples R China

来源：

SYNLETT | 2015年 / 26卷 / 09期

基金：

中国国家自然科学基金;

关键词：

palladium-catalyzed; Heck-type coupling; C-N cleavage; control experiment; mechanism; CARBONYL-COMPOUNDS; DIRECT ARYLATION; MANNICH-BASES; BOND; CHALCONES; FUNCTIONALIZATION; (HETERO)ARENES; OLEFINATION; SEQUENCE; KETONES;

D O I：

10.1055/s-0034-1379911

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed Heck-type coupling method between arenes and ketone Mannich bases via C-N cleavage to synthesize chalcones is reported. This protocol offers good yields and tolerates a broad range of functional groups. Based on the extensive experimental data, we propose a plausible coulping mechanism.

引用

页码：1253 / 1257

页数：5

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