Design, characterization and in vitro evaluation of stavudine-loaded microspheres

被引：1

作者：

Vaghani, Subhash S. ^{[1
]}

Sureja, Sunil ^{[2
]}

Singh, Sachin ^{[2
]}

Gurjar, Mitesh ^{[2
]}

Jivani, N. P. ^{[1
]}

Patel, Madhabhai M. ^{[3
]}

机构：

[1] Smt RB Patel Mahila Pharm Coll, Dept Pharmaceut, Rajkot 360040, Gujarat, India

[2] PES Coll Pharm, Dept Pharmaceut, Bangalore, Karnataka, India

[3] Kalol Inst Pharm, Kalol, Gujarat, India

来源：

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2011年 / 16卷 / 02期

关键词：

Stavudine; microspheres; solvent evaporation; Eudragit RS 100; Eudragit RL 100; diffusion controlled; RELEASE; MICROPARTICLES;

D O I：

10.3109/10837450903544559

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of the present study was to prepare and evaluate microspheres of Eudragit containing an antiviral drug stavudine. Microspheres were prepared by O/O solvent evaporation method using acetone/liquid paraffin system. The prepared microspheres were characterized for their micromeretic properties and entrapment efficiency; as well by Fourier transformed infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD) and scanning electron microscopy (SEM) which revealed the crystalline nature of drug in a final state. The in vitro studies revealed the controlled release of drug from microspheres up to 12 h and the best fit release kinetics was achieved with a Higuchi plot and found to be diffusion controlled. The yields of preparation and entrapment efficiencies were very high with a larger particle size for all the formulations. Mean particle size, entrapment efficiency and production yield were highly influenced by the type of polymer and polymer concentration.

引用

页码：146 / 151

页数：6

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