Concise synthesis of benzoindolizidine derivatives and bioactivity evaluation

被引：0

作者：

Cui, Mingbo ^{[1
]}

Wang, Kailiang ^{[1
]}

Wang, Qingmin ^{[1
]}

Huang, Runqiu ^{[1
]}

机构：

[1] Nankai Univ, Res Inst Elemento Organ Chem, Tianjin Key Lab Pesticide Sci, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

LETTERS IN ORGANIC CHEMISTRY | 2008年 / 5卷 / 02期

关键词：

benzoindolizidine; hydrochloride salt; picrate; synthesis; antiviral activity; anticancer activity;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Due to the profound cytotoxicities and interesting biochemical aspects, phenanthroindolizidine alkaloids have received attention as potential therapeutic leads. To define the features of the molecule that are essential for their excellent bioactivities, we have synthesized two hexahydropyrrolo[1,2-b] isoquinolines and their hydrochloride salts and picrates concisely and evaluated their antiviral and anticancer activities. We found that the replacement of the phenanthrene with a benzene in phenanthroindolizidine alkaloids observably decreased their antiviral and anticancer activities, and thus the phenanthrene in phenanthroindolizidine alkaloids is essential for high antiviral and anticancer activities.

引用

页码：98 / 102

页数：5

共 32 条

[1] Alkaloids from Cynanchum komarovii with inhibitory activity against the tobacco mosaic virus [J].