Diabetes mellitus and survival in cystic fibrosis patients after lung transplantation

被引：32
作者：
Hofer, Markus [1 ]
Schmid, Christoph [2 ]
Benden, Christian [1 ]
Speich, Rudolf [3 ]
Inci, Ilhan [4 ]
Weder, Walter [4 ]
Boehler, Annette [1 ]
机构：
[1] Univ Zurich Hosp, Div Pulm Med, CH-8091 Zurich, Switzerland
[2] Univ Zurich Hosp, Div Endocrinol, CH-8091 Zurich, Switzerland
[3] Univ Zurich Hosp, Div Internal Med, CH-8091 Zurich, Switzerland
[4] Univ Zurich Hosp, Div Thorac Surg, CH-8091 Zurich, Switzerland
来源：
JOURNAL OF CYSTIC FIBROSIS | 2012年 / 11卷 / 02期
关键词：
Cystic fibrosis; Lung transplantation; Diabetes mellitus; Bronchiolitis obliterans syndrome; BRONCHIOLITIS-OBLITERANS-SYNDROME; PHENOTYPE; MORTALITY; GENOTYPE; UPDATE; COHORT; PREVALENCE; GUIDELINES; EXPERIENCE; DELTA-F508;
D O I：
10.1016/j.jcf.2011.10.005
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Background: Diabetes mellitus (DM) is common in CF and associated with more severe disease. It is unclear whether DM influences outcome of lung transplantation (LTx). Methods: One hundred twenty-three CF patients evaluated for LTx at our centre were included. Survival was calculated. Results: Patients with and without DM did not differ with regard to gender, age, FEV1 and BMI prior to LTx. Eighty patients (65%) had a diagnosis of DM before and 13 (11%) only after LTx. Recipients with DM had a significantly higher 1- and 5-year survival (89% and 71%) than those without (71% and 51%). In the multivariate Cox-regression analysis, DM had no impact on LTx-survival. Conclusions: One- and five-year survival rates after LTx tend to be better in CF recipients with DM compared to those without DM. No impact of DM on the development of BOS was found. (C) 2011 Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.
引用
收藏
页码：131 / 136
页数：6
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