Targeting Sphingosine-1-Phosphate in Hematologic Malignancies

被引：3

作者：

Stevenson, Christina E. ^{[2
]}

Takabe, Kazuaki ^{[2
]}

Nagahashi, Masayuki ^{[2
]}

Milstien, Sheldon ^{[1
]}

Spiegel, Sarah ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Sch Med, Dept Biochem & Mol Biol, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Sch Med, Dept Surg, Div Surg Oncol, Richmond, VA 23298 USA

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2011年 / 11卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Sphingosine-1-phosphate; sphingosine kinase; sphingosine-1-phosphate receptors; leukemia; lymphoma; hematologic malignancies; IMATINIB-INDUCED APOPTOSIS; NF-KAPPA-B; SPHINGOSINE; 1-PHOSPHATE; ESSENTIAL REQUIREMENT; LEUKEMIA-CELLS; LYMPHOMA-CELLS; UP-REGULATION; FTY720; KINASE; INHIBITION;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid mediator that regulates several processes important for hematologic cancer progression. S1P is generated by two sphingosine kinases, SphK1 and SphK2, and is exported outside the cell, where it activates specific cell surface S1P G-protein coupled receptors in autocrine/paracrine manner, coined "inside-out signaling". In this review, we highlight the importance of SphK1 and inside-out signaling by S1P in hematologic malignancy. We also summarize the results of studies targeting the SphK1/S1P/S1P receptor axis and the effects of the S1P receptor modulator, FTY720, in hematologic malignancy.

引用

页码：794 / 798

页数：5

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