Initial post marketing experience with lacosamide in adult patients with epilepsy

被引：19

作者：

Harden, Cynthia L. ^{[1
]}

Cohn, Aaron ^{[2
]}

Lowe, Merredith ^{[2
]}

Serrano, Enrique ^{[2
]}

机构：

[1] N Shore Long Isl Jewish Hlth Syst, Hofstra N Shore LIJ Sch Med, Cushing Neurosci Inst, New Hyde Pk, NY 11040 USA

[2] Univ Miami, Miller Sch Med, Dept Neurol, Div Epilepsy, Miami, FL 33136 USA

来源：

EPILEPSY RESEARCH | 2012年 / 98卷 / 2-3期

关键词：

Epilepsy; Lacosamide; Responder rate; Dose; Correlation; Adverse effects;

D O I：

10.1016/j.eplepsyres.2011.09.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The outcomes of adult epilepsy patients prescribed lacosamide for additional seizure control. Responders were defined as having at least a 50% decrease in seizure frequency Sixty-seven patients were evaluated. Forty-six out of 67 patients (69%) were responders. Twelve of 14 patients not taking sodium channel-acting AEDs were responders (86%) and 34/53 patients taking sodium channel-acting AEDs were responders (64%) (difference not significant). (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：260 / 263

页数：4

共 9 条

[1] Barnes K.L., 2000, COMPREHENSIVE CLIN N, P43
[2] Lacosamide:: A review of preclinical properties
Beyreuther, Bettina K.
Freitag, Joachim
Heers, Cara
Krebsfaenger, Niels
Scharfenecker, Ute
Stoehr, Thomas
[J]. CNS DRUG REVIEWS, 2007, 13 (01): : 21 - 42
[3] From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels
Catterall, WA
[J]. NEURON, 2000, 26 (01) : 13 - 25
[4] Lacosamide as adjunctive therapy for partial-onset seizures: A randomized controlled trial
Chung, Steve
Sperling, Michael R.
Biton, Victor
Krauss, Gregory
Hebert, David
Rudd, G. David
Doty, Pamela
[J]. EPILEPSIA, 2010, 51 (06) : 958 - 967
[5] *FDA, 2008, FDA LAB INF
[6] Harris J.A., 2010, CNS NEUROSCI THE OCT
[7] Shorvon S.D., 2010, Handbook of Epilepsy Treatment
[8] Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy
Stoehr, Thomas
Kupferberg, Harvey J.
Stables, James P.
Choi, Daeock
Harris, Robert H.
Kohn, Harold
Walton, Nancy
White, H. Steve
[J]. EPILEPSY RESEARCH, 2007, 74 (2-3) : 147 - 154
[9] Walker M.C., 2009, TREATMENT EPILEPSY, P91

← 1 →