One-pot three component synthesis of 5-allyl-1,2,3-triazoles using copper(I) acetylides

被引：5
作者：
Reddy, Parigi Raghavendar
Cui, Lianji
Ryu, Jae-Sang [1 ]
机构：
[1] Ewha Womans Univ, Coll Pharm, 52 Ewhayeodae Gil, Seoul 03760, South Korea
来源：
RSC ADVANCES | 2018年 / 8卷 / 05期
基金：
新加坡国家研究基金会;
关键词：
AZIDE-ALKYNE CYCLOADDITION; CLICK CHEMISTRY; CHEMICAL-BIOLOGY; POLYMERS; 1,2,3-TRIAZOLES; ARCHITECTURES; ROTAXANES; INSIGHTS; CATALYST; DRUG;
D O I：
10.1039/c7ra12889d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
One-pot three-component reactions using copper(I) acetylide, azide, allyl iodide, and NaOH have been developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further transformed into a variety of 1,2,3-triazole-fused bi-/tricyclic scaffolds. This method offers the most efficient, convenient, and practical route towards useful polycyclic scaffolds in moderate to excellent yields.
引用
收藏
页码：2759 / 2767
页数：9
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