Advances in Antimicrobial Microneedle Patches for Combating Infections

被引：364

作者：

Jamaledin, Rezvan ^{[1
]}

Yiu, Cynthia K. Y. ^{[2
]}

Zare, Ehsan N. ^{[3
]}

Niu, Li-Na ^{[4
,5
]}

Vecchione, Raffaele ^{[1
]}

Chen, Guojun ^{[6
,7
]}

Gu, Zhen ^{[6
,7
]}

Tay, Franklin R. ^{[8
]}

Makvandi, Pooyan ^{[9
,10
,11
]}

机构：

[1] Ist Italiano Tecnol, Ctr Adv Biomat Hlth Care Iit CRIB, I-80125 Naples, Italy

[2] Univ Hong Kong, Prince Philip Dent Hosp, Paediat Dent & Orthodont, Fac Dent, Hong Kong, Peoples R China

[3] Damghan Univ, Sch Chem, Damghan 3671641167, Iran

[4] Fourth Mil Med Univ, State Key Lab Mil Stomatol Natl Clin Res, Ctr Oral Dis, Sch Stomatol, Xian 710000, Shaanxi, Peoples R China

[5] Fourth Mil Med Univ, Shaanxi Key Lab Stomatol, Dept Prosthodont, Sch Stomatol, Xian 710000, Shaanxi, Peoples R China

[6] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[7] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA

[8] Augusta Univ, Grad Sch, Augusta, GA 30912 USA

[9] CNR, Inst Polymers Composites & Biomat IPCB, I-80125 Naples, Italy

[10] Shahid Chamran Univ Ahvaz, Dept Chem, Fac Sci, Ahwaz 6153753843, Iran

[11] Iran Univ Med Sci, Fac Adv Technol Med, Dept Med Nanotechnol, Tehran 1449614535, Iran

来源：

ADVANCED MATERIALS | 2020年 / 32卷 / 33期

关键词：

antibacterial microneedles; antifungal patches; antiviral microneedles; ocular microneedle patches; transdermal drug delivery; transdermal microneedle patches; TRANSDERMAL DRUG-DELIVERY; INDIVIDUAL PATIENT DATA; LABEL-FREE DETECTION; POLYMERIC MICROPARTICLES; STAPHYLOCOCCUS-AUREUS; GOLD NANOPARTICLES; MICROBIAL BIOFILMS; AMPHOTERICIN-B; ARRAY PATCH; REAL-TIME;

D O I：

10.1002/adma.202002129

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Skin infections caused by bacteria, viruses and fungi are difficult to treat by conventional topical administration because of poor drug penetration across the stratum corneum. This results in low bioavailability of drugs to the infection site, as well as the lack of prolonged release. Emerging antimicrobial transdermal and ocular microneedle patches have become promising medical devices for the delivery of various antibacterial, antifungal, and antiviral therapeutics. In the present review, skin anatomy and its barriers along with skin infection are discussed. Potential strategies for designing antimicrobial microneedles and their targeted therapy are outlined. Finally, biosensing microneedle patches associated with personalized drug therapy and selective toxicity toward specific microbial species are discussed.

引用

页数：29

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