Anti-MRSA Sesquiterpenes from the Semi-Mangrove Plant Myoporum bontioides A. Gray

被引：24

作者：

Dong, Li-Mei ^{[1
]}

Huang, Li-Lan ^{[2
]}

Dai, Hang ^{[2
]}

Xu, Qiao-Lin ^{[3
]}

Ouyang, Jin-Kui ^{[1
]}

Jia, Xu-Chao ^{[4
]}

Gu, Wen-Xiang ^{[2
]}

Tan, Jian-Wen ^{[1
]}

机构：

[1] South China Agr Univ, Coll Forestry & Landscape Architecture, Guangdong Key Lab Innovat Dev & Utilizat Forest P, State Key Lab Conservat & Utilizat Subtrop Agrobi, Guangzhou 510642, Guangdong, Peoples R China

[2] South China Agr Univ, Coll Mat & Energy, Guangzhou 510642, Guangdong, Peoples R China

[3] Guangdong Acad Forestry, Guangdong Prov Key Lab Biocontrol Forest Dis & Pe, Guangzhou 510520, Guangdong, Peoples R China

[4] Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Guangdong Key Lab Agr Prod Proc, Minist Agr,Key Lab Funct Foods, Guangzhou 510610, Guangdong, Peoples R China

来源：

MARINE DRUGS | 2018年 / 16卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Myoporum bontioides; methicillin-resistant Staphylococcus aureus (MRSA); sesquiterpene alkaloids; RESISTANT STAPHYLOCOCCUS-AUREUS; TERPENOID CHEMISTRY; INHIBITORY-ACTIVITY; (-)-EPINGAIONE; INFECTIONS; DAPTOMYCIN; VANCOMYCIN; KETONES; DRUGS;

D O I：

10.3390/md16110438

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The striking rise of methicillin-resistant Staphylococcus aureus (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant Myoporum bontioides A. Gray, which led to the isolation of two new sesquiterpene alkaloids (1 and 2) and six known furanosesquiterpenes (3-8). Their structures were elucidated on the basis of extensive analysis of their 1D, 2D NMR and mass spectroscopic data. These two new alkaloids (1 and 2) displayed potent anti-MRSA activity with MIC value of 6.25 g/mL. This is the first report of sesquiterpene alkaloids from the plants of Myoporum genus and their anti-MRSA activity.

引用

页数：8

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