Design, synthesis, and drug solubilising properties of the first folate-calix[4]arene conjugate

被引：24
作者：
Consoli, Grazia M. L. [1 ]
Granata, Giuseppe [1 ]
Geraci, Corrada [1 ]
机构：
[1] CNR, Ist Chim Biomol, I-95126 Catania, Italy
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 19期
关键词：
CLICK CHEMISTRY; IN-VIVO; ACID; OLIGODEOXYNUCLEOTIDES; NANOPARTICLES; PROLIFERATION; CYTOTOXICITY; CALIXARENES; DERIVATIVES; INHIBITION;
D O I：
10.1039/c1ob06032e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first example of a folate-calix[4]arene conjugate was designed and synthesized via microwave-assisted click chemistry. In PBS medium at physiological pH, the conjugate formed soluble aggregates and showed the capability to improve the water-solubility of a hydrophobic drug model, such as indomethacin.
引用
收藏
页码：6491 / 6495
页数：5
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