ERp57/PDIA3: new insight

被引：52

作者：

Chichiarelli, Silvia ^{[1
]}

Altieri, Fabio ^{[1
]}

Paglia, Giuliano ^{[1
]}

Rubini, Elisabetta ^{[1
,2
]}

Minacori, Marco ^{[1
]}

Eufemi, Margherita ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Biochem Sci A Rossi Fanelli, Ple A Moro 5, I-00185 Rome, Italy

[2] Enrico Ed Enrica Sovena Fdn, Rome, Italy

来源：

CELLULAR & MOLECULAR BIOLOGY LETTERS | 2022年 / 27卷 / 01期

关键词：

ERp57; PDIA3; PDI inhibitors; Punicalagin; Vitamin D3; Cancer; Infections; Nervous system; Cardiovascular system; Fertility; PROTEIN DISULFIDE-ISOMERASE; VITAMIN-D; BINDING-PROTEIN; MOLECULAR CHAPERONE; THERAPEUTIC TARGETS; RAPID RESPONSES; ERP57; CANCER; FAMILY; PDIA3;

D O I：

10.1186/s11658-022-00315-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ERp57/PDIA3 protein is a pleiotropic member of the PDIs family and, although predominantly located in the endoplasmic reticulum (ER), has indeed been found in other cellular compartments, such as the nucleus or the cell membrane. ERp57/PDIA3 is an important research target considering it can be found in various subcellular locations. This protein is involved in many different physiological and pathological processes, and our review describes new data on its functions and summarizes some ligands identified as PDIA3-specific inhibitors.

引用

页数：18

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