Alcohol Consumption and Mild Cognitive Impairment: A Mendelian Randomization Study from Rural China

被引:5
作者
Cui, Yi [1 ]
Si, Wei [1 ,2 ]
Zhu, Chen [1 ,2 ]
Zhao, Qiran [1 ,2 ]
机构
[1] China Agr Univ, Coll Econ & Management, Beijing 100083, Peoples R China
[2] China Agr Univ, Acad Global Food Econ & Policy, Beijing 100083, Peoples R China
基金
中国国家自然科学基金;
关键词
alcohol consumption; mild cognitive impairment; Mendelian randomization; rural China; RISK-FACTORS; ALZHEIMERS-DISEASE; DEMENTIA; PREVALENCE; AGE; DRINKING; PEOPLE; SEX; MEN; PROGRESSION;
D O I
10.3390/nu14173596
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Alcohol consumption has been associated with the risk of mild cognitive impairment (MCI) in observational studies. The result is inconsistent and whether the association is causal remains unknown. To examine the causal effect of alcohol consumption on MCI in rural China, this study used a cross-sectional dataset that included 1966 observations collected in rural China, of which 235 observations' genotyping were collected. All participants accepted the MCI evaluation using Mini-Cog and were asked about the participants' alcohol consumption behavior. The causal effect of alcohol consumption on MCI was investigated by Mendelian randomization (MR) of genetic variation in the aldehyde dehydrogenase 2 (ALDH2 rs671) gene. The risk of MCI in Chinese rural areas was 43%. Alcohol consumption was causally associated with a higher risk of MCI under MR design. Parameter estimates of drinking or not (b = 0.271, p = 0.007, 95% CI = 0.073 to 0.469), drinking frequency during the past 30 days (b = 0.016, p = 0.003, 95% CI = 0.005 to 0.027), and the weekly ethanol consumption (b = 0.132, p = 0.004, 95% CI = 0.042 to 0.223) were all positive and statistically significant at the 5% level. In conclusion, there was a high risk of MCI in rural China, and alcohol consumption was causally associated with a higher risk of MCI.
引用
收藏
页数:10
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