Macrophages and neutrophils cooperate in immune responses to Leishmania infection

被引：9
作者：
Filardy, Alessandra A. [1 ,2 ]
Pires, Dayana R. [1 ,2 ]
DosReis, George A. [1 ,2 ]
机构：
[1] Univ Fed Rio de Janeiro, Ctr Ciencias Saude, Inst Biofis Carlos Chagas Filho, Ilha Fundao, BR-21949900 Rio De Janeiro, Brazil
[2] Inst Nacl Saude & Ambiente Regiao Amazon, Ctr Ciencias Saude, Brazilian Natl Res Council CNPq, BR-21949900 Rio De Janeiro, Brazil
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2011年 / 68卷 / 11期
关键词：
Neutrophil; Macrophage; Leishmania; Apoptosis; Phagocytosis; Cytokines; TOLL-LIKE RECEPTOR-4; CUTANEOUS LEISHMANIASIS; APOPTOTIC CELLS; ALTERNATIVE ACTIVATION; INFLAMMATORY RESPONSE; EXTRACELLULAR TRAPS; SUSCEPTIBLE MICE; MAJOR INFECTION; WOUND REPAIR; BALB/C MICE;
D O I：
10.1007/s00018-011-0653-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neutrophils and macrophages are phagocytic cells that cooperate during inflammation and tissue repair. Neutrophils undergo apoptosis and are engulfed by macrophages. Engulfment modulates macrophage activation and microbicidal activity. Infection by Leishmania takes place in the context of tissue repair. This article discusses cellular and molecular mechanisms involved in the intimate cooperation of neutrophils and macrophages in Leishmania infection.
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收藏
页码：1863 / 1870
页数：8
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