Nonalcoholic Fatty Liver Disease, Diabetes, Obesity, and Hepatocellular Carcinoma

被引：147

作者：

Noureddin, Mazen ^{[1
]}

Rinella, Mary E. ^{[2
]}

机构：

[1] Univ So Calif, Keck Sch Med, Div Gastrointestinal & Liver Dis, Los Angeles, CA 90033 USA

[2] Northwestern Univ, Feinberg Sch Med, Div Gastroenterol & Hepatol, Chicago, IL 60611 USA

来源：

CLINICS IN LIVER DISEASE | 2015年 / 19卷 / 02期

关键词：

Nonalcoholic steatohepatitis; Cirrhosis; Noncirrhotic; Insulin resistance; Hepatocellular carcinoma; Obesity; Diabetes; Chemoprevention; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; TERM-FOLLOW-UP; S-ADENOSYLMETHIONINE; RISK-FACTORS; METABOLIC SYNDROME; NATURAL-HISTORY; CANCER-RISK; HEPATITIS-C; KAPPA-B;

D O I：

10.1016/j.cld.2015.01.012

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Diabetes and obesity are associated with nonalcoholic fatty liver disease (NAFLD) and an increased incidence of hepatocellular carcinoma (HOC). NAFLD is the commonest cause of chronic liver disease. HOC can develop in NAFLD patients even without cirrhosis, suggesting an association between the metabolic process and HOC and raising a concern that many cancers could be missed given high NAFLD prevalence and screening limitations. The increasing prevalence of these conditions and lack of effective treatments necessitate a better understanding of their connection. This article defines the known interrelationships and common pathways between NAFLD, diabetes, obesity and HOC and possible chemoprevention strategies.

引用

页码：361 / +

页数：20

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