Steroid constituents from the soft coral Sinularia microspiculata

被引：16

作者：

Nguyen Van Thanh ^{[1
]}

Ninh Thi Ngoc ^{[1
]}

Hoang Le Tuan Anh ^{[1
]}

Do Cong Thung ^{[2
]}

Do Thi Thao ^{[3
]}

Nguyen Xuan Cuong ^{[1
]}

Nguyen Hoai Nam ^{[1
]}

Phan Van Kiem ^{[1
]}

Chau Van Minh ^{[1
]}

机构：

[1] VAST, Inst Marine Biochem IMBC, Hanoi, Vietnam

[2] VAST, IMER, Haiphong, Vietnam

[3] VAST, Inst Biotechnol IBT, Hanoi, Vietnam

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2016年 / 18卷 / 10期

关键词：

Sinularia microspiculata; Alcyoniidae; soft coral; steroid; MARINE SPONGE; POLYHYDROXYLATED STEROLS; POLYOXYGENATED STEROIDS; 26,27-CYCLOSTEROLS; CYTOTOXICITY; XESTOSPONGIA; METABOLITES; DERIVATIVES;

D O I：

10.1080/10286020.2016.1173676

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A methanol extract of the soft coral Sinularia microspiculata revealed five sterols, including two new compounds. Using combined chromatographic and spectroscopic experiments, the new compounds were found to be 7-oxogorgosterol (1) and 16-hydroxysarcosterol (2). Their structures were determined on the basis of spectroscopic data (H-1 and C-13 NMR, HSQC, HMBC, H-1-H-1 COSY, NOESY, and FT-ICR-MS) and by comparing obtained results to the values indicated in previous studies. Among the isolated compounds, 3 showed weak cytotoxic effects against HL-60 (IC50=89.02 +/- 9.93M) cell line, whereas 5 was weakly active against HL-60 (IC50=82.80 +/- 13.65M) and SK-Mel2 (IC50=72.32 +/- 1.30M) cell lines.

引用

收藏

页码：938 / 944

页数：7

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