From Breast to the Brain: Unraveling the Puzzle of Metastasis Organotropism

被引：19

作者：

Hu, Guohong ^{[1
]}

Kang, Yibin ^{[1
]}

Wang, Xiao-Fan ^{[2
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

[2] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

来源：

JOURNAL OF MOLECULAR CELL BIOLOGY | 2009年 / 1卷 / 01期

关键词：

CANCER METASTASIS; GENES; LUNG;

D O I：

10.1093/jmcb/mjp005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Metastatic colonization of different target organs is a highly selective process that depends on specialized properties of tumor cells. In a recent Nature paper, Massague and colleagues built on their earlier success in functional genomic analysis of breast cancer metastasis to bone and lung and reported the identification of breast cancer brain metastasis genes, highlighting the importance of the stromal environment in the development of organ-specific metastasis.

引用

页码：3 / 5

页数：3

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