Impact of expert pathology review in skin adnexal carcinoma diagnosis: Analysis of 2573 patients from the French CARADERM network

被引：11

作者：

Battistella, Maxime ^{[1
]}

Balme, Brigitte ^{[2
]}

Jullie, Marie-Laure ^{[3
]}

Zimmermann, Ute ^{[4
]}

Carlotti, Agnes ^{[5
]}

Crinquette, Marie ^{[6
]}

Frouin, Eric ^{[7
]}

Macagno, Nicolas ^{[8
,9
]}

Ortonne, Nicolas ^{[10
]}

Lamant, Laurence ^{[11
]}

de la Fouchardiere, Arnaud ^{[12
]}

Aubriot-lorton, Marie-Helene ^{[13
]}

Durand, Luc ^{[14
]}

Josselin, Nicolas ^{[15
]}

Franck, Frederic ^{[16
]}

Chatelain, Denis ^{[17
]}

Lemasson, Gilles ^{[18
]}

Algros, Marie-Paule ^{[19
]}

Durlach, Anne ^{[20
]}

Machet, Marie-Christine ^{[21
]}

Courville, Philippe ^{[22
]}

Osio, Amelie ^{[1
]}

Seris, Alice ^{[23
]}

Mortier, Laurent ^{[24
]}

Jouary, Thomas ^{[23
]}

Cribier, Bernard ^{[25
,26
]}

机构：

[1] Univ Paris, St Louis Hosp, AP HP, Pathol Dept,INSERM,U976, F-75010 Paris, France

[2] CHU Lyon Sud, Pathol Dept, Lyon, France

[3] CHU Bordeaux, Pathol Dept, Bordeaux, France

[4] Ambroise Pare Hosp, AP HP, Pathol Dept, Boulogne, France

[5] Cochin Hosp, AP HP, Pathol Dept, Paris, France

[6] CHU Lille, Pathol Dept, Lille, France

[7] Poitiers Univ, Pathol Dept, Lab Inflammat Tissus & Epitheliaux & Cytokines, Poitiers Univ Hosp,EA4331, Poitiers, France

[8] Aix Marseille Univ, Timone Univ Hosp, AP HM, INSERM U1251,Pathol Dept, Marseille, France

[9] Aix Marseille Univ, Timone Univ Hosp, AP HM, Dept Pathol,INSERM U1251, Marseille, France

[10] Henri Mondor Hosp, AP HP, Pathol Dept, Creteil, France

[11] Inst Univ Canc Toulouse Oncopole, Dept Pathol, Toulouse, France

[12] Ctr Leon Berard, Pathol Dept, Lyon, France

[13] CHU Dijon, Pathol Dept, Dijon, France

[14] CHU Montpellier, Pathol Dept, Montpellier, France

[15] CHU Nantes, IHP Nantes, Nantes, France

[16] CHU Clermont Ferrand, Pathol Dept, Clermont Ferrand, France

[17] CHU Amiens, Pathol Dept, Amiens, France

[18] CHU Brest, Pathol Dept, Brest, France

[19] CHU Besancon, Pathol Dept, Besancon, France

[20] CHU Reims, Pathol Dept, Reims, France

[21] CHU Tours, Pathol Dept, Tours, France

[22] CHU Rouen, Pathol Dept, Rouen, France

[23] Francois Mitterrand Hosp, Dermatol Unit, Pau, France

[24] Univ Lille, Dermatol Dept, CHU Lille, Lille, France

[25] Univ Strasbourg, Dermatol & Dermatopathol, Univ Hosp, Strasbourg, France

[26] Univ Strasbourg, Fac Med, Strasbourg, France

来源：

EUROPEAN JOURNAL OF CANCER | 2022年 / 163卷

关键词：

Skin adnexal carcinoma; Sweat gland carcinoma; Hair follicle carcinoma; Sebaceous carcinoma; Expert pathological review; Misdiagnosis; Rare cancer network; BASAL-CELL CARCINOMA; TRICHOBLASTIC TUMORS; SURVIVAL; SPIRADENOMA; MUTATION; CANCER;

D O I：

10.1016/j.ejca.2021.11.027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: To prospectively assess the impact of expert pathological review of skin adnexal carcinoma diagnosis in France.Methods: From 2014 to 2019, 2573 samples from patients with newly diagnosed or suspected skin adnexal carcinomas were reviewed prospectively by expert pathologists through the national CARADERM (CAncers RAres DERMatologiques) network. Changes in diagnosis between referral and expert review were analysed regarding their potential impact on patient care or prognosis.Results: The samples comprised 2205 newly diagnosed adnexal carcinomas, 129 benign adnexal tumours, 136 basal cell carcinomas, 74 squamous cell carcinomas, six cutaneous metastases and 13 other malignancies. There were 930 (42%) sweat gland carcinomas, of which porocarcinoma (261; 11.8%), microcystic adnexal carcinoma (125; 5.7%) and hidradenocarcinoma (109; 4.9%) were the most frequent subtypes; 778 (35%) hair follicle carcinomas, 238 (11%) sebaceous carcinomas and 212 (10%) extramammary Paget diseases/mammary-like anogenital gland adenocarcinomas. A diagnostic change between referral and expert review occurred in 503 (21.3%) patients, significantly higher for cases sent with a provisional diagnosis seeking an expert second opinion (45.7%) than for cases sent with a formal diagnosis (2.8%) (p < .0001). Sweat gland carcinomas were more prone to diagnostic discrepancies than other tumours (p < .0001), including 1.8% of patients with sweat gland carcinoma subtype misclassification with predicted clinical impact. Changes between benign and malignant conditions occurred in 117 samples (5% of patients).Conclusion: The study provides a unique description of the distribution of skin adnexal carcinomas and highlights the importance of expert review for these rare cancers. Optimal clinical management was impacted in a significant proportion of patients.(c) 2021 Elsevier Ltd. All rights reserved.

引用

页码：211 / 221

页数：11

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