The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease

被引：188

作者：

Dursun, Erdinc ^{[1
]}

Gezen-Ak, Duygu ^{[1
]}

Hanagasi, Hasmet ^{[2
]}

Bilgic, Basar ^{[2
]}

Lohmann, Ebba ^{[2
]}

Ertan, Sibel ^{[3
]}

Atasoy, Irem L. ^{[1
]}

Alaylioglu, Merve ^{[1
]}

Araz, Omur Selin ^{[1
]}

Onal, Burak ^{[4
]}

Gunduz, Aysegul ^{[3
]}

Apaydin, Hulya ^{[3
]}

Kiziltan, Gunes ^{[3
]}

Ulutin, Turgut ^{[1
]}

Gurvit, Hakan ^{[2
]}

Yilmazer, Selma ^{[1
]}

机构：

[1] Istanbul Univ, Dept Med Biol, Cerrahpasa Fac Med, Istanbul, Turkey

[2] Istanbul Univ, Behav Neurol & Movement Disorders Unit, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey

[3] Istanbul Univ, Cerrahpasa Fac Med, Dept Neurol, Istanbul, Turkey

[4] Istanbul Univ, Cerrahpasa Fac Med, Dept Med Pharmacol, Istanbul, Turkey

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 283卷

关键词：

Alzheimer's disease; Mild cognitive impairment (MCI); Parkinson's disease (PD); Interleukin 1 alpha (IL-1 alpha); Interleukin 1 beta (IL-1 beta); Interleukin 6 (IL-6); Alpha-2 macroglobulin (alpha 2-macroglobulin); Tumor necrosis factor alpha (TNF alpha); Brain derived neurotrophic factor (BDNF); Interleukin 10 (IL-10); Heat shock protein 90 (Hsp90); Biomarker; NECROSIS-FACTOR-ALPHA; CEREBROSPINAL-FLUID; VASCULAR DEMENTIA; TNF-ALPHA; PLASMA-LEVELS; INFLAMMATORY MARKERS; CYTOKINES; IL-1-BETA; BRAIN; ALPHA(1)-ANTICHYMOTRYPSIN;

D O I：

10.1016/j.jneuroim.2015.04.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Alzheimer's disease (EOAD, LOAD), mild cognitive impairment (MCI), Parkinson's disease (PD) and healthy controls were included to determine the serum interleukin-Is (IL-1 alpha, IL-1 beta), IL-6 and alpha-2-macroglobulin (alpha M-2) levels using ELISA. IL-6 might be a significant contributor to the inflammatory response in LOAD. The MCI data indicate that IL-1s, alpha M-2 and BDNF are somehow related, and this relationship might allow MCI patients to be more similar to the healthy controls. A correlation analysis of multiple biomarkers in different neurodegenerative disorders might be more useful than determining the levels of a single cytokine in a single disorder. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：50 / 57

页数：8

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