Effect of aromatic substitution on antimuscarinic activity of 2-phenyl-2-cyclohexyl-4-[(dimethylamino)methyl]-1,3-dioxolanes

被引：0
|
作者：
Angeli, P
Brasili, L
Franchini, S
Giardinà, D
Gulini, U
Marucci, G
机构：
[1] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, Italy
[2] Univ Modena, Dipartimento Sci Farmaceut, I-41100 Modena, Italy
来源：
MEDICINAL CHEMISTRY RESEARCH | 1999年 / 9卷 / 02期
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D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 2-substituted 1,3-dioxolane ligands were synthesized and tested as muscarinic antagonists. The compounds display moderate to high affinity for the three receptor subtypes M-1-M-3, With some of them showing a modest selectivity for the M-1 subtype.
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页码：89 / 97
页数：9
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