Head direction cells in the postsubiculum do not show replay of prior waking sequences during sleep

被引:18
作者
Brandon, Mark P. [1 ,2 ]
Bogaard, Andrew R.
Andrews, Chris M.
Hasselmo, Michael E. [1 ,2 ]
机构
[1] Boston Univ, Dept Psychol, Boston, MA 02215 USA
[2] Boston Univ, Program Neurosci, Ctr Memory & Brain, Boston, MA 02215 USA
关键词
head direction cells; postsubiculum; sleep replay; retrieval; rapid-eye-movement sleep; medial temporal lobe; local field potential; FREELY-MOVING RATS; TEMPORALLY STRUCTURED REPLAY; HIPPOCAMPAL PLACE CELLS; ENTORHINAL CORTEX; ANTERIOR THALAMUS; GRID CELLS; PATH-INTEGRATION; FIRING PROPERTIES; NEURAL ACTIVITY; UNIT-ACTIVITY;
D O I
10.1002/hipo.20924
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
During slow-wave sleep (SWS) and rapid eye movement (REM) sleep, hippocampal place cells in the rat show replay of sequences previously observed during waking. We tested the hypothesis from computational modeling that the temporal structure of REM sleep replay could arise from an interplay of place cells with head direction cells in the postsubiculum. Physiological single-unit recording was performed simultaneously from five or more head direction or place by head direction cells in the postsubiculum during running on a circular track allowing sampling of a full range of head directions, and during sleep periods before and after running on the circular track. Data analysis compared the spiking activity during individual REM periods with waking as in previous analysis procedures for REM sleep. We also used a new procedure comparing groups of similar runs during waking with REM sleep periods. There was no consistent evidence for a statistically significant correlation of the temporal structure of spiking during REM sleep with spiking during waking running periods. Thus, the spiking activity of head direction cells during REM sleep does not show replay of head direction cell activity occurring during a previous waking period of running on the task. In addition, we compared the spiking of postsubiculum neurons during hippocampal sharp wave ripple events. We show that head direction cells are not activated during sharp wave ripples, whereas neurons responsive to place in the postsubiculum show reliable spiking at ripple events. (c) 2011 Wiley Periodicals, Inc.
引用
收藏
页码:604 / 618
页数:15
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