MDR1 polymorphisms affect the outcome of Chinese multiple myeloma patients

被引：4

作者：

Xiao, Zhengrui ^{[1
,2
]}

Yin, Guangli ^{[1
,2
]}

Ni, Ying ^{[1
,2
]}

Qu, Xiaoyan ^{[1
,2
]}

Wu, Hanxin ^{[1
,2
]}

Lu, Hua ^{[1
,2
]}

Qian, Sixuan ^{[1
,2
]}

Chen, Lijuan ^{[1
,2
]}

Li, Jianyong ^{[1
,2
]}

Qiu, Hairong ^{[1
,2
]}

Miao, Kourong ^{[1
,2
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Jiangsu Prov Hosp, Dept Hematol, Nanjing 210029, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Collaborat Innovat Ctr Canc Personalized Med, Nanjing 210029, Jiangsu, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2017年 / 95卷

基金：

中国国家自然科学基金;

关键词：

Multiple myeloma; MDR1; Polymorphism; Prognosis; 1 GENE MDR1/ABCB1; C3435T; ASSOCIATION; EFFLUX;

D O I：

10.1016/j.biopha.2017.08.142

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective: To illustrate the association of MDR1 (Multidrug Resistance 1) polymorphisms at loci 1236, 2677, 3435 and the prognosis of multiple myeloma (MM) in Jiangsu population. Methods: A total of 129 MM patients were recruited from Jiangsu Province, China. The DNA was extracted from white blood cells (WBC) of peripheral blood and was amplified by polymerase chain reaction-allele specific primers (PCR-ASP). MDR1 polymorphisms at 3 loci were analyzed by electrophoresis followed by photograph or DNA direct sequencing. The association between the MDR1 and clinical outcomes were calculated by Graphpad and SPSS. Results: MDR1 alleles at locus C1236T with T had significant lower calcium level in MM patients compared with C. The genotype CT had a significantly prolonged progress free survival (PFS) compared genotype CC at locus C1236T (median time: 48 months vs. 28 months, respectively; p=0.0062; HR=0.21; 95% CI0.061-0.715) while patients carrying T allele (CT and TT) at locus C3435T had a longer PFS than patients without T allele (CC) (median time: 60 months vs. 29 months, respectively; p=0.038; HR=0.508; 95% CI 0.264-0.978). And a borderline significance was found in haplotype at loci 2677-3435 and PFS. No significant findings were revealed between OS and MDR1 polymorphisms. Conclusion: MDR1 polymorphisms could affect the prognosis of multiple myeloma whereas more samples and a longer follow-up are also needed.

引用

页码：743 / 748

页数：6

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