Prophylactic effect of green tea polyphenols against liver and kidney injury induced by fenitrothion insecticide

被引：67

作者：

Elhalwagy, Manal E. A. ^{[1
]}

Darwish, Nevine S. ^{[2
]}

Zaher, Enass M. ^{[3
]}

机构：

[1] Agr Res Ctr, Pesticide Cent Lab, Dept Mammalian Toxicol, Giza 12618, Egypt

[2] Res Inst Ophthalmol, Dept Histol, Giza 12211, Egypt

[3] Agr Res Ctr, Plant Protect Res Inst, Dept Harmful Anim, Giza 12618, Egypt

来源：

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY | 2008年 / 91卷 / 02期

关键词：

organophosphorus insecticide; fenitrothion; green tea extract; oxidative stress; liver; kidney; alanine aminotransferase (ALT); aspartate aminotransferase (AST); albumin; urea; creatinine; glutathione S-transferase; total glutathione;

D O I：

10.1016/j.pestbp.2008.01.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ameliorative effect of daily administrated dose of green tea extract (60 mg polyphenols/animal/day) was investigated on albino rats Rattus norvegicus (150-180 gm) intoxicated with 1/30 and 1/60 LD(50) fenitrothion organophosphate insecticide for 28 days. Blood samples were taken at 14 and 28 days for further biochemical parameters. Histopathological studies were carried out in the liver and kidney at the end of the experiment. Significant inhibition in plasma cholinesterase (ChE), a biomarker of Ops, was recorded. Damage in the liver and kidney tissues was observed and confirmed with elevation of plasma alanine aminotransferase (ALT), aspartate aminotaransferase (AST), albumin, urea and creatinine, as well as an elevation in the oxidative stress (OS) marker malondialdehyde (MDA). Decrease in total glutathione (GSH) content in erythrocytes and fluctuation in glutathione S-transferase (GST) activity in plasma was also observed. Green tea supplementation (60 mg/animal/day) partially counteracts the toxic effect of fenitrothion on oxidative stress parameters and repairs tissue damage in the liver and kidney, especially when supplemented to 1/60 LD50 intoxicated animals depending on the duration. It seems that enzyme and metabolite markers of these organs need more time to be restored to the control level. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：81 / 89

页数：9

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