Synthesis, Structural Characterization and Antitumor Activity of Copper(II) Complex of 4-(2-Hydroxy-3-chlorine)pheny1-2,2′:6′,2′-terpyridine

被引：1

作者：

Zhong Yu-Jun ^{[1
]}

Chen Zhen-Feng ^{[1
]}

Liang Hong ^{[1
]}

机构：

[1] Guangxi Normal Univ, Sch Chem & Pharm, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Guangxi, Peoples R China

来源：

CHINESE JOURNAL OF INORGANIC CHEMISTRY | 2019年 / 35卷 / 11期

关键词：

tribipyridine; copperan complex; antitumor activity; cell apoptosis; cell cycle; IN-VITRO; CYTOTOXICITY; TERPYRIDINE;

D O I：

10.11862/CJIC.2019.253

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new copper(II) complex [Cu-2(mu-L-kappa O,O)(2)Cl-2] (1) with 4-(2-hydroxy-3-chloro)phenyl-2,2':6',2' -tribipyridine (HL) as ligand was synthesized and characterized by elemental analysis, NMR, ESI-MS as well as single crystal X-ray diffraction analysis. Complex 1 is a binuclear structure, and the central copper(II) is coordinated by one Cl- anion, two N atoms and two hydroxyl O atoms from L- to form five-coordination distorted square-pyramid geometric configurations; two copper centers are bridged by two hydroxyl O atoms. MTT assay was employed to test the inhibitory activities of complex 1 against five selected cancer cell lines. The results showed that inhibition rate of MGC80-3 cells was the highest, reaching (84.30 +/- 1.28)%, and its IC50 value was (3.36 +/- 0.43) mu mol.L-1. Flow cytometry analytical results indicated that complex 1 could induce apoptosis of MGC80-3 cells. Under the complex 1 concentration of 4.5 mu mol.L-1, the MGC80-3 cell apoptosis percentage was 42.2%. Complex 1 arrested MGC80-3 cells in Gl phase, thereby inhibiting the growth of tumor cells. CCDC: 1959094.

引用

页码：2089 / 2094

页数：6

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