Optically activated and interrogated plasmonic hydrogels for applications in wound healing

被引：17

作者：

Milanesi, Alessio ^{[1
,2
]}

Magni, Giada ^{[1
]}

Centi, Sonia ^{[1
]}

Schifino, Gioacchino ^{[3
]}

Aluigi, Annalisa ^{[3
]}

Khlebtsov, Boris N. ^{[4
]}

Cavigli, Lucia ^{[1
]}

Barucci, Andrea ^{[1
]}

Khlebtsov, Nikolai G. ^{[4
,5
]}

Ratto, Fulvio ^{[1
]}

Rossi, Francesca ^{[1
]}

Pini, Roberto ^{[1
]}

机构：

[1] CNR, Ist Fis Applicata Nello Carrara, Via Madonna Piano 10, I-50019 Florence, Italy

[2] Univ Firenze, Dipartimento Chim Ugo Schiff, Florence, Italy

[3] CNR, Ist Sintesi Organ & Fotoreatt, Bologna, Italy

[4] Russian Acad Sci, Inst Biochem & Physiol Plants & Microorganisms, Saratov, Russia

[5] Saratov NG Chernyshevskii State Univ, Fac Nano & Biomed Technol, Saratov, Russia

来源：

JOURNAL OF BIOPHOTONICS | 2020年 / 13卷 / 09期

基金：

俄罗斯基础研究基金会;

关键词：

chitosan hydrogels; electrospinning; gold nanorods; laser welding; oxidative stress monitoring; silver nanoparticles; ENHANCED RAMAN-SCATTERING; GOLD NANORODS; SILVER NANOPARTICLES; OXIDATIVE STRESS; ANTIBACTERIAL PROPERTIES; PEROXIDE; CHITOSAN; FABRICATION; DISSOLUTION; FILMS;

D O I：

10.1002/jbio.202000135

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We disclose the use of hybrid materials featuring Au/Ag core/shell nanorods in porous chitosan/polyvinyl alcohol scaffolds for applications in tissue engineering and wound healing. The combination of Au and Ag in a single construct provides synergistic opportunities for optical activation of functions as near infrared laser tissue bonding, and remote interrogation to return parameters of prognostic relevance in wound healing monitoring. In particular, the bimetallic component ensures optical tunability, enhanced shelf life and photothermal stability, serves as a reservoir of germicidal silver cations, and changes in near-infrared and visible color according to the environmental level of oxidative stress. At the same time, the polymeric blend is ideal to bind connective tissue upon photothermal activation, and to support fabrication processes that provide high porosity, such as electrospinning, thus putting all the premises for cellular repopulation and antimicrobial protection.

引用

页数：10

共 105 条

[1] Wound healing potential of curcumin cross-linked chitosan/ polyvinyl alcohol [J].

Abbas, Mazhar ;

Hussain, Tariq ;

Arshad, Muhammad ;

Ansari, Abdur Rahman ;

Irshad, Asma ;

Nisar, Jan ;

Hussain, Fida ;

Masood, Nasir ;

Nazir, Arif ;

Iqbal, Munawar .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 140 :871-876

[2] Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems [J].

Abdelgawad, Abdelrahman M. ;

Hudson, Samuel M. ;

Rojas, Orlando J. .

CARBOHYDRATE POLYMERS, 2014, 100 :166-178

[3] Antimicrobial chitosan-PVA hydrogel as a nanoreactor and immobilizing matrix for silver nanoparticles [J].

Agnihotri, Shekhar ;

Mukherji, Soumyo ;

Mukherji, Suparna .

APPLIED NANOSCIENCE, 2012, 2 (03) :179-188

[4] Novel electrospun chitosan/polyvinyl alcohol/zinc oxide nanofibrous mats with antibacterial and antioxidant properties for diabetic wound healing [J].

Ahmed, Rashid ;

Tariq, Muhammad ;

Ali, Imran ;

Asghar, Rehana ;

Khanam, P. Noorunnisa ;

Augustine, Robin ;

Hasan, Anwarul .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 120 :385-393

[5] Gold nanorods: Synthesis and optical properties [J].

Alekseeva, A. V. ;

Bogatyrev, V. A. ;

Khlebtsov, B. N. ;

Mel'nikov, A. G. ;

Dykman, L. A. ;

Khlebtsov, N. G. .

COLLOID JOURNAL, 2006, 68 (06) :661-678

[6] Green synthesized PLA/silver nanoparticle probe for sensing of hydrogen peroxide in biological samples [J].

Alipilakkotte, Shebi ;

Sreejith, Lisa .

MATERIALS LETTERS, 2018, 217 :33-38

[7] Structure and properties of keratin/PEO blend nanofibres [J].

Aluigi, Annalisa ;

Vineis, Claudia ;

Varesano, Alessio ;

Mazzuchetti, Giorgio ;

Ferrero, Franco ;

Tonin, Claudio .

EUROPEAN POLYMER JOURNAL, 2008, 44 (08) :2465-2475

[8] A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications [J].

Baker, Maribel I. ;

Walsh, Steven P. ;

Schwartz, Zvi ;

Boyan, Barbara D. .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2012, 100B (05) :1451-1457

[9] Supramolecular gels 'in action' [J].

Banerjee, Supratim ;

Das, Rajat K. ;

Maitra, Uday .

JOURNAL OF MATERIALS CHEMISTRY, 2009, 19 (37) :6649-6687

[10] Chitosan: An undisputed bio-fabrication material for tissue engineering and bio-sensing applications [J].

Baranwal, Anupriya ;

Kumar, Ashutosh ;

Priyadharshini, A. ;

Oggu, Gopi Suresh ;

Bhatnagar, Ira ;

Srivastava, Ananya ;

Chandra, Pranjal .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 110 :110-123

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