An efficient α-hydroxylation of carbonyls using the HOF•CH3CN complex

被引：25

作者：

Dayan, S ^{[1
]}

Bareket, Y ^{[1
]}

Rozen, S ^{[1
]}

机构：

[1] Tel Aviv Univ, Raymond & Beverly Sackler Fac Exact Sci, Sch Chem, IL-69978 Tel Aviv, Israel

来源：

TETRAHEDRON | 1999年 / 55卷 / 12期

关键词：

F-2; HOF center dot CH3CN; hydroxy carbonyl; alpha-hydroxylation;

D O I：

10.1016/S0040-4020(98)01173-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The complex HOF.CH3CN, made directly from fluorine and aqueous acetonitrile, was used for alpha-hydroxylation of various ketones, esters and acids via their trimethyl silyl enol ethers. The reaction is usually complete in a few minutes at room temperature or below and has high yields. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3657 / 3664

页数：8

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