CONVENIENT AND EFFICIENT SYNTHESIS OF SOME NOVEL FUSED THIENO PYRIMIDINES USING GEWALD'S REACTION

被引：17

作者：

Nirogi, Ramakrishna V. S. ^{[1
]}

Kambhampati, Rama Sastri

Kothmirkar, Prabhakar

Arepalli, Sobhanadri

Pamuleti, Narasimha Reddy G.

Shinde, Anil K.

Dubey, P. K. ^{[2
]}

机构：

[1] Suven Life Sci Ltd, Serene Chambers, Discovery Res, Med Chem, Hyderabad 500034, Andhra Pradesh, India

[2] Jawaharlal Nehru Technol Univ, Dept Chem, Hyderabad, Andhra Pradesh, India

来源：

SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 19期

关键词：

Cyclizations; fused thiophenes; Gewald reaction; thieno pyrimidines; DERIVATIVES; AGENTS; MOIETY;

D O I：

10.1080/00397911.2010.515357

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several functionalized thienopyrimidines were synthesized by a facile synthetic method, which includes Gewald's reaction, and were characterized by spectral and analytical data. These functionalized thienopyrimidines were converted to various new chemical entities of biological importance, such as 2-piperazinymethyl thienopyrimidines (6, 8), 4-dimethylaminoethoxy thienopyrimidines (11), and 3-dimethylaminoethyl thienopyrimidines (12). All the compounds thus synthesized were screened for their invitro biological activities. Some of the compounds displayed promising serotonin 5-HT6 receptor antagonist activities.

引用

页码：2835 / 2851

页数：17

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