Kinetic and solvent isotope effects in oxidation of halogen derivatives of tyramine catalyzed by monoamine oxidase A

被引：1

作者：

Pajak, Malgorzata ^{[1
]}

机构：

[1] Warsaw Univ, Dept Chem, Pasteur 1 Str, PL-02093 Warsaw, Poland

来源：

JOURNAL OF BIOCHEMISTRY | 2020年 / 167卷 / 01期

关键词：

deuterium; enzyme mechanism; 3 '-halo-tyramines; isotope effects; MAO A; AMINE OXIDATION; PH-DEPENDENCE; MECHANISM; METABOLISM; BINDING; ACID; H-2;

D O I：

10.1093/jb/mvz089

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The isotope effects approach was used to elucidate the mechanism of oxidative deamination of 3'-halotyramines, catalyzed by monoamine oxidase A (EC 1.4.3.4). The numerical values of kinetic isotope effect (KIE) and solvent isotope effect (SIE) were established using a non-competitive spectrophotometric technique. Based upon KIE and SIE values, some of the mechanistic details of investigated reaction were discussed.

引用

页码：49 / 54

页数：6

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