Role of gut microbiota in the modulation of atherosclerosis-associated immune response

被引：68

作者：

Chistiakov, Dmitry A. ^{[1
,2
]}

Bobryshev, Yuri V. ^{[3
,4
,5
]}

Kozarov, Emil ^{[6
]}

Sobenin, Igor A. ^{[3
,7
]}

Orekhov, Alexander N. ^{[3
,8
,9
]}

机构：

[1] Res Ctr Childrens Hlth, Dept Mol Genet Diagnost & Cell Biol, Div Lab Med, Inst Pediat, Moscow, Russia

[2] Mt Sinai Med Ctr, Mt Sinai Community Clin Oncol Program, Mt Sinai Comprehens Canc Ctr, Miami Beach, FL 33140 USA

[3] Russian Acad Sci, Inst Gen Pathol & Pathophysiol, Lab Angiopathol, Moscow, Russia

[4] Univ New S Wales, Fac Med, Sch Med Sci, Sydney, NSW 2052, Australia

[5] Univ Western Sydney, Sch Med, Campbelltown, NSW, Australia

[6] Columbia Univ, Dept Oral & Diagnost Sci, New York, NY USA

[7] Russian Cardiol Res & Prod Complex, Med Genet Lab, Moscow, Russia

[8] Skolkovo Innovat Ctr, Inst Atherosclerosis, Moscow, Russia

[9] Moscow MV Lomonosov State Univ, Dept Biophys, Fac Biol, Moscow, Russia

来源：

FRONTIERS IN MICROBIOLOGY | 2015年 / 6卷

基金：

俄罗斯科学基金会;

关键词：

intestinal microbiota; immune system; atherosclerosis; atherogenesis; arteries; REVERSE CHOLESTEROL TRANSPORT; LOW-DENSITY-LIPOPROTEIN; FOAM CELL-FORMATION; FREE FATTY-ACIDS; INTESTINAL MICROBIOTA; GERM-FREE; REDUCES ATHEROSCLEROSIS; INFLAMMATORY CHANGES; PROTOCATECHUIC ACID; AUTOIMMUNE-DISEASES;

D O I：

10.3389/fmicb.2015.00671

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Inflammation and metabolic abnormalities are linked to each other. At present, pathogenic inflammatory response was recognized as a major player in metabolic diseases. In humans, intestinal microflora could significantly influence the development of metabolic diseases including atherosclerosis. Commensal bacteria were shown to activate inflammatory pathways through altering lipid metabolism in adipocytes, macrophages, and vascular cells, inducing insulin resistance, and producing trimethylamine-N-oxide. However, gut microbiota could also play the atheroprotective role associated with anthocyanin metabolism and administration of probiotics and their components. Here, we review the mechanisms by which the gut microbiota may influence atherogenesis.

引用

页数：7

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