Neuroendocrine tumors of the lung: clinicopathological and molecular features

被引：21

作者：

Iyoda, Akira ^{[1
]}

Azuma, Yoko ^{[1
]}

Sano, Atsushi ^{[1
]}

机构：

[1] Toho Univ, Div Chest Surg, Dept Surg, Sch Med,Ota Ku, 6-11-1 Omori Nishi, Tokyo 1438541, Japan

来源：

SURGERY TODAY | 2020年 / 50卷 / 12期

关键词：

Neuroendocrine tumor; Lung; Surgery; SMALL-CELL CARCINOMA; FACTOR RECEPTOR MUTATION; MULTICENTER-PHASE-II; C-KIT PROTEIN; ADJUVANT CHEMOTHERAPY; EXPRESSION; CISPLATIN; CANCER; ETOPOSIDE; DIAGNOSIS;

D O I：

10.1007/s00595-020-01988-7

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

In 1970, neuroendocrine tumors of the lung were classified into three categories: typical carcinoid (TC), atypical carcinoid (AC), and small cell lung carcinoma (SCLC). The third edition of the World Health Organization (WHO) classification in 1999 defined large cell neuroendocrine carcinoma (LCNEC) as a variant of large cell carcinomas, whereas the fourth edition of the WHO classification redefined LCNEC as a neuroendocrine tumor. Currently, neuroendocrine tumors of the lung are classified into four main categories: TC, AC, LCNEC, and SCLC. Although the treatments for TC, AC, and SCLC have not changed remarkably, the treatment strategy for LCNEC is not yet established because of its reclassification from a variant of "large cell carcinoma" to a new category of "neuroendocrine tumor". In this review article, we discuss the pathological findings, biological behavior, and treatment of neuroendocrine tumors of the lung.

引用

页码：1578 / 1584

页数：7

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