Silver Cluster-Porphyrin-Assembled Materials as Advanced Bioprotective Materials for Combating Superbacteria

被引:56
作者
Cao, Man [1 ,2 ]
Wang, Shan [1 ,2 ]
Hu, Jia-Hua [1 ,2 ]
Lu, Bing-Huai [3 ,4 ]
Wang, Qian-You [1 ,2 ]
Zang, Shuang-Quan [1 ,2 ]
机构
[1] Zhengzhou Univ, Henan Key Lab Crystalline Mol Funct Mat, Henan Int Joint Lab Tumor Theranost Cluster Mat, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China
[2] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China
[3] China Japan Friendship Hosp, Natl Clin Res Ctr Resp Dis, Dept Pulm & Crit Care Med, Lab Clin Microbiol & Infect Dis, Beijing 100029, Peoples R China
[4] Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, China Guangdong Key Lab Emerging Infect Dis, Shenzhen 518055, Peoples R China
基金
中国国家自然科学基金;
关键词
antibiotic-resistant bacteria; atomically precise silver cluster; charge transfer; photocatalyst; reactive oxygen species (ROS); silver cluster-porphyrin assembled materials; INACTIVATION; PHOTOCATALYST; NANOCLUSTERS; OXYGEN;
D O I
10.1002/advs.202103721
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Superbugs are bacteria that have grown resistant to most antibiotics, seriously threating the health of people. Silver (Ag) nanoparticles are known to exert a wide-spectrum antimicrobial property, yet remains challenging against superbugs. Here, Ag clusters are assembled using porphyrin-based linkers and a novel framework structure (Ag-9-AgTPyP) is produced, in which nine-nuclearity Ag-9 clusters are uniformly separated by Ag-centered porphyrin units (AgTPyP) in two dimensions, demonstrating open permeant porosity. Ag-9-AgTPyP eliminates over 99.99999% and 99.999% methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (P. aeruginosa) within 2 h upon visible-light irradiation, which are superior to a majority of bacteria inactivation photocatalysts. The novel-established long-term charge-transfer states from AgTPyP to adjacent Ag-9 cluster that has preferential affinity to O-2 greatly promote reactive oxygen species (ROS) production efficiency; and its unique framework accelerates the ROS transportation. Personal protective equipment (masks and protective suits) incorporating Ag-9-AgTPyP film also shows excellent performances against superbugs. This superbugs-killing efficiency is unprecedented among silver complexes and porphyrin derivatives. Utilizing efficient photogenerated electrons and holes between metal cluster and linkers can open up new interests of research in photocatalytic areas.
引用
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页数:10
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