Genome Sequence and Assembly of Bos indicus

被引:85
作者
Canavez, Flavio C. [1 ]
Luche, Douglas D. [1 ]
Stothard, Paul [2 ]
Leite, Katia R. M. [1 ]
Sousa-Canavez, Juliana M. [1 ]
Plastow, Graham [2 ]
Meidanis, Joao [3 ,4 ]
Souza, Maria Angelica [3 ]
Feijao, Pedro [4 ]
Moore, Steve S. [2 ]
Camara-Lopes, Luiz H. [1 ]
机构
[1] Genoa Biotecnol SA, Dept Mol Biol, BR-04004030 Sao Paulo, Brazil
[2] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB, Canada
[3] Scylla Bioinformat, Bioinformat Div, Campinas, SP, Brazil
[4] Univ Estadual Campinas, Inst Comp, Campinas, SP, Brazil
关键词
Bos indicus; bovine; genome; Nellore; sequencing; BOVINE GENOME; CATTLE; ORIGINS;
D O I
10.1093/jhered/esr153
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cattle are divided into 2 groups referred to as taurine and indicine, both of which have been under strong artificial selection due to their importance for human nutrition. A side effect of this domestication includes a loss of genetic diversity within each specialized breed. Recently, the first taurine genome was sequenced and assembled, allowing for a better understanding of this ruminant species. However, genetic information from indicine breeds has been limited. Here, we present the first genome sequence of an indicine breed (Nellore) generated with 52X coverage by SOLiD sequencing platform. As expected, both genomes share high similarity at the nucleotide level for all autosomes and the X chromosome. Regarding the Y chromosome, the homology was considerably lower, most likely due to uncompleted assembly of the taurine Y chromosome. We were also able to cover 97% of the annotated taurine protein-coding genes.
引用
收藏
页码:342 / 348
页数:7
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