Successful haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide in a child with X-linked chronic granulomatous disease: A first report in Asia

被引：0

作者：

Janjindamai, Chawisa ^{[1
]}

Manuyakorn, Wiparat ^{[1
,2
]}

Anurathapan, Usanarat ^{[1
]}

Pakakasama, Samart ^{[1
]}

Wattanasirichaigoon, Duangrurdee ^{[1
]}

Kamchaisatian, Wasu ^{[1
]}

Benjaponpitak, Suwat ^{[1
]}

Hongeng, Suradej ^{[1
]}

机构：

[1] Mahidol Univ, Fac Med, Dept Pediat, Ramathibodi Hosp, Bangkok, Thailand

[2] Mahidol Univ, Fac Med, Dept Pediat, Div Allergy & Immunol,Ramathibodi Hosp, Rama 6 Rd, Bangkok 10400, Thailand

来源：

ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY | 2022年 / 40卷 / 03期

关键词：

Haploidentical transplantation; Hematopoietic stem cell transplantation; Chronic granulomatous disease; Cyclophosphamide; Graft-Versus-Host Disease;

D O I：

10.12932/ap-290419-0551

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: HLA-matched hematopoietic stem cell transplantation (HSCT) is the curative treatment for chronic granulomatous disease (CGD). Objective: To report a case of X-linked CGD with active infection successfully treated by haploidentical HSCT with post-transplant high dose cyclophosphamide (PTCY). Methods: A 5-year-old Thai boy with CGD was undergone for haploidentical HSCT using PTCY with correction of the phagocytic function. He presented with Chromobacterium violaceum liver abscess at the age of 9 months and experienced recurrent perianal abscess and invasive pulmonary aspergillosis even receiving antimicrobial prophylaxis. PTCY was given on day 3 and 4, after CD34+ cells infusion. Results: The peripheral blood-nucleated cell chimerism showed 100% on day 16 and remained 100%. Dihydrorhodamine (DHR) assay on day 108 and day 214 showed normal results. Currently at 22 months post HSCT, he does not receive antibiotic and anti-fungal prophylaxis. Conclusions: Haploidentical HSCT with PTCY could be an effective treatment option for children with CGD.

引用

页码：278 / 282

页数：5

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