Structure-Activity Relationships of Butyrophilin 3 Ligands

被引：21

作者：

Wiemer, Andrew J. ^{[1
,2
]}

机构：

[1] Univ Connecticut, Dept Pharmaceut Sci, 69N Eagleville Rd, Storrs, CT 06269 USA

[2] Univ Connecticut, Inst Syst Genom, 69N Eagleville Rd, Storrs, CT 06269 USA

来源：

CHEMMEDCHEM | 2020年 / 15卷 / 12期

基金：

美国国家卫生研究院;

关键词：

bisphosphonate; gammadelta; phosphoantigen; phospholipids; receptors; DELTA T-CELLS; NONPEPTIDE ANTIGENS; DIPHOSPHATE SYNTHASE; BIOLOGICAL-ACTIVITY; ZOLEDRONIC ACID; IN-VIVO; GAMMA; PYROPHOSPHATE; ACTIVATION; PHOSPHOANTIGENS;

D O I：

10.1002/cmdc.202000198

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phosphoantigens (pAgs) are small phosphorus-containing molecules that stimulate V gamma 9V delta 2 T cells with sub-nanomolar cellular potency. Recent work has revealed that these compounds work through binding to the transmembrane immunoglobulin butyrophilin 3A1 (BTN3A1) within its intracellular B30.2 domain. Engagement of BTN3A1 is critical to the formation of an immune synapse between cells that contain pAgs and the V gamma 9V delta 2 T cells. This minireview summarizes the structure-activity relationships of pAgs and their implications to the mechanisms of butyrophilin 3 activation leading to V gamma 9V delta 2 T cell response.

引用

页码：1030 / 1039

页数：10

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