Chloride channels: A molecular perspective

被引:113
作者
Jentsch, TJ
机构
[1] Ctr. for Molec. Neurobiology Hamburg, Hamburg University, D-20246 Hamburg
关键词
D O I
10.1016/S0959-4388(96)80112-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Plasma membrane Cl- channels perform a variety of functions, including central of excitability in neurons and muscle, cell volume regulation and transepithelial transport. Structurally, three classes of Cl- channels have been identified: ligand-gated, postsynaptic Cl- channels (e.g. GABA and glycine receptors); the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels (which belong to the traffic ATPase superfamily); and the CLC family of Cl- channels. Recent developments of note include further characterization of the expanding CLC Cl- channel family, advances in understanding the regulation of the CFTR Cl- channel and its emergent role as a regulator of other channels, clarification of issues related to swelling-activated Cl- channels, and the discovery that several co-transporter molecules are now known to induce Cl- currents in Xenopus oocytes.
引用
收藏
页码:303 / 310
页数:8
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