The role of corticotropin-releasing factor and noradrenaline in stress-related responses, and the inter-relationships between the two systems

被引：80

作者：

Dunn, Adrian J. ^{[1
,2
]}

Swiergiel, Artur H. ^{[2
,3
]}

机构：

[1] Univ Hawaii, Pacific Biosci Res Ctr, Honolulu, HI 96822 USA

[2] Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol Toxicol & Neurosci, Shreveport, LA 71105 USA

[3] Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol Toxicol & Neurosci, Shreveport, LA 71105 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2008年 / 583卷 / 2-3期

关键词：

corticotropin-releasing factor (CRF); noradrenaline; stress; feed-forward; locus coeruleus; depression;

D O I：

10.1016/j.ejphar.2007.11.069

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Substantial evidence indicates that brain neurons containing and secreting noradrenaline and corticotropin-releasing factor (CRF) are activated during stress.. and that physiological and behavioural responses observed during stress can be induced by exogenous administration of CRF and adrenoceptor agonists. This review focusses on the evidence for the involvement of these two factors in stress-related responses, and the interrelationships between them. The possible abnormalities of these two systems in depressive illness are also discussed. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：186 / 193

页数：8

共 73 条

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